Previous studies in the dog have demonstrated that intravascular mechanoreceptors have effects on renal excretory function via reflex modulation of arginine vasopressin, renin and catecholamine levels and efferent renal nerve activity. These afferent neural pathways are thus believed to provide the link between changes in blood volume and appropriate changes in salt and water excretion. It has been further hypothesized that a depressed sensitivity or resetting of these receptors may contribute to the fluid retention seen in heart failure and that the efficacy of cardiac glycoside treatment in this condition may be partially due to this treatment increasing the sensitivity of these receptor mechanisms. However, the role of these neural mechanisms in maintaining circulatory and body fluid homeostasis in the primate is still unclear. Studies using the primate model have demonstrated that afferent neural control of renal function in this species is less sensitive than in the dog and may be linked more to control of blood pressure than control of blood volume. Furthermore, it has been hypothesized that, unlike the dog, the renal nerves may not play a major role in directly affecting renal sodium reabsorption in the primate which suggests that efferent neural control of renal excretion may be less important in this species also. The studies in this proposal will extend these observations and more completely explore the possible importance of these neural mechanisms in the nonhuman primate.
The specific aims are: 1) to determine if acute and chronic renal denervation affect the antinatriuretic response to orthostasis and if chronic renal denervation causes the kidney to become hypersensitive to circulating norepinephrine, (2) to determine if there is interaction between atrial receptor and carotid sinus baroreceptor control of renal function and if cardiac glycoside treatment sensitizes these effects, (3) to determine if cardiac glycosides affect vagal cardiopulmonary baroreceptor and sinoaortic baroreceptor control of renal nerve activity during changes in blood volume. (4) to determine if vagal afferent pathways have tonic effects on arginine vasopressin, renin and catecholamine levels and baroreceptor interaction with these effects, (5) to directly determine the relative importance of cardiac receptors and baroreceptors in modulating the secretion of vasopressin, renin and catecholamines during changes in central blood volume and (6) to determine if cardiac receptors and/or baroreceptors are responsible for the interaction beteen volumetric and osmotic control of vasopressin.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL001383-02
Application #
3073746
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1984-09-01
Project End
1989-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Texas A&M University
Department
Type
Schools of Medicine
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845
Benjamin, B A; Peterson, T V (1995) Effect of proANF-(31--67) on sodium excretion in conscious monkeys. Am J Physiol 269:R1351-5
Peterson, T V; Benjamin, B A (1992) The heart and control of renal excretion: neural and endocrine mechanisms. FASEB J 6:2923-32
Peterson, T V; Benjamin, B A; Hurst, N L et al. (1991) Renal nerves and postprandial renal excretion in the conscious monkey. Am J Physiol 261:R1197-203
Peterson, T V; Benjamin, B A; Hurst, N L (1988) Renal nerves and renal responses to volume expansion in conscious monkeys. Am J Physiol 255:R388-94
Peterson, T V; Hurst, N L; Richardson, J A (1987) Renal nerves and renal responses to head-up tilt in dogs. Am J Physiol 252:R979-86
Peterson, T V; Benjamin, B A; Hurst, N L (1987) Effect of vagotomy and thoracic sympathectomy on responses of the monkey to water immersion. J Appl Physiol 63:2476-81
Peterson, T V; McBride, D G; Seideman, S K et al. (1986) Cardiopulmonary and sinoaortic baroreceptors and volume expansion in the monkey. Basic Res Cardiol 81:123-33
Peterson, T V; Hurst, N L; Richardson, J A (1985) Renal nerves and initial excretory responses to recumbency: a species comparison. Am J Physiol 249:R747-52