Abstract

My current research is focused on understanding the relative contributions of convective and diffusive processes governing oxygen delivery, in particular how increasing the affinity of the hemoglobin molecule for oxygen impacts on oxygen exchange. The initial series of studies proposed here will enable us to better characterize the diffusional interactions between large microvessels (arterioles and venules) and the capillaries under normoxic and hypoxic conditions, with and without a decrease in systemic hematocrit. The next two series of studies will enable us to explore the impact of an increased hemoglobin oxygen affinity on oxygen transport in the presence of an elevated oxygen demand with and without reduced levels of inspired oxygen tension and systemic hematocrit, thereby testing the limits of oxygen delivery in this system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Modified Research Career Development Award (K04)
Project #
5K04HL002602-03
Application #
2210248
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1992-01-01
Project End
1996-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Saint Louis University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103

  Publications

Ellsworth, Mary L (2004) Red blood cell-derived ATP as a regulator of skeletal muscle perfusion. Med Sci Sports Exerc 36:35-41
Sprague, R S; Stephenson, A H; Ellsworth, M L et al. (2001) Impaired release of ATP from red blood cells of humans with primary pulmonary hypertension. Exp Biol Med (Maywood) 226:434-9
Ellsworth, M L (2000) The red blood cell as an oxygen sensor: what is the evidence? Acta Physiol Scand 168:551-9
Collins, D M; McCullough, W T; Ellsworth, M L (1998) Conducted vascular responses: communication across the capillary bed. Microvasc Res 56:43-53
Sprague, R S; Ellsworth, M L; Stephenson, A H et al. (1998) Deformation-induced ATP release from red blood cells requires CFTR activity. Am J Physiol 275:H1726-32
McCullough, W T; Collins, D M; Ellsworth, M L (1997) Arteriolar responses to extracellular ATP in striated muscle. Am J Physiol 272:H1886-91
Sprague, R S; Ellsworth, M L; Stephenson, A H et al. (1996) ATP: the red blood cell link to NO and local control of the pulmonary circulation. Am J Physiol 271:H2717-22
Ellsworth, M L; Forrester, T; Ellis, C G et al. (1995) The erythrocyte as a regulator of vascular tone. Am J Physiol 269:H2155-61
Stein, J C; Ellsworth, M L (1993) Capillary oxygen transport during severe hypoxia: role of hemoglobin oxygen affinity. J Appl Physiol 75:1601-7
Stein, J C; Ellis, C G; Ellsworth, M L (1993) Relationship between capillary and systemic venous PO2 during nonhypoxic and hypoxic ventilation. Am J Physiol 265:H537-42