Continued career development will come from a combination of new research projects and new questions from older projects, leading to new methods and to new as well as continuing collaborations. This will be facilitated by the thriving neuroscience community at Emory University, which includes many principal investigators conducting research on issues related to drug abuse, and by the recent expansion of faculty and breadth of research within the Dept. of Pharmacology. The proposed research focuses on the behavioral pharmacology of opioids and, to a smaller extent, cocaine, and reflects current grant support from NIDA.
Specific aims i nclude testing hypotheses about acute opioid dependence in rats and squirrel monkeys and the functional state of endogenous opioid systems in adult rats that had undergone daily maternal separation during the early postnatal period. Trainees at various academic levels - undergraduate, pre- and postdoctoral - will participate in this research program each year. An important goal will be to provide them with the intellectual skills needed for a career of research on the behavioral pharmacology of drugs of abuse. In addition, the Candidate will continue to engage in nonresearch activities that contribute to overall career development, such as teaching neurobehavioral pharmacology, membership on journal editorial boards and government advisory committees, and holding elected office in scientific organizations.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Award (K05)
Project #
5K05DA000008-30
Application #
6784494
Study Section
Special Emphasis Panel (ZDA1-KXA-N (03))
Program Officer
Schnur, Paul
Project Start
1975-09-01
Project End
2005-08-31
Budget Start
2004-09-10
Budget End
2005-08-31
Support Year
30
Fiscal Year
2004
Total Cost
$119,264
Indirect Cost
Name
Emory University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
White, David A; Michaels, Clifford C; Holtzman, Stephen G (2008) Periadolescent male but not female rats have higher motor activity in response to morphine than do adult rats. Pharmacol Biochem Behav 89:188-99
White, David A; Ballard, Michael E; Harmon, Alvin C et al. (2008) Acute delta- and kappa-opioid agonist pretreatment potentiates opioid antagonist-induced suppression of water consumption. Brain Res Bull 76:597-604
Michaels, Clifford C; Holtzman, Stephen G (2007) Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated rats. Pharmacol Biochem Behav 86:784-96
Michaels, Clifford C; Easterling, Keith W; Holtzman, Stephen G (2007) Maternal separation alters ICSS responding in adult male and female rats, but morphine and naltrexone have little affect on that behavior. Brain Res Bull 73:310-8
White, David A; Kalinichev, Mikhail; Holtzman, Stephen G (2007) Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the rat. Brain Res 1149:141-8
Michaels, Clifford C; Holtzman, Stephen G (2006) Neonatal stress and litter composition alter sucrose intake in both rat dam and offspring. Physiol Behav 89:735-41
White, David A; Hwang, M Lisa; Holtzman, Stephen G (2005) Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat. Pharmacol Biochem Behav 81:451-8
White, David A; Holtzman, Stephen G (2005) Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult rats. Eur J Pharmacol 528:119-23
White, David A; Holtzman, Stephen G (2005) Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey: a further characterization. J Pharmacol Exp Ther 314:374-82
Jain, Raka; Holtzman, Stephen G (2005) Caffeine induces differential cross tolerance to the amphetamine-like discriminative stimulus effects of dopaminergic agonists. Brain Res Bull 65:415-21

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