This is a resubmission of a competing continuation application for a SSA. The major goals are to extend research on: (1) risk and protective factors involved in adult tobacco and drug use/abuse/dependence, extending into early mid-life; (2) testing models of pathways to tobacco and drug use/abuse/dependence; (3) interactive effects of risk and protective factors; and (4) consequences of tobacco and drug use on adolescent and adult functioning. To achieve this, I wilt expand prior research by: (1) including samples of inner-city youngsters and parental drug abusers; (2) comparing the etiologies of tobacco and drug use/abuse/dependence, and their relation to psychopathology; (3) studying the intra- and intergenerational transmission of drug-prone characteristics; (4) examining cultural factors associated with tobacco and drug use/abuse/dependence; (5) studying the interaction of genetic and environmental factors on drug use/abuse/dependence; and (6) examining factors related to AIDS transmission behavior and coping with AIDS. In order to achieve these goals, an integrated program of research is underway, involving five funded large-scale projects: Studies 1A and 1B: Longitudinal studies of 976 children from ages 1-10 to early mid-life and their mothers; Studies 2A and 2B: Studies of African-American and Puerto Rican inner city youth and their mothers; Study 3: A multigenerational study of 324 offspring of the original study children in Study 2A; Study 4: A study of Black and White South African adolescents, age 12-17; Study 5: A study of 500 male HIV+ and HIV- injection drug-using fathers and their children; Study P1: A study of childhood factors for drug use/abuse extending into early mid-life, and Study P2: A study of gene-environment interactions related to drug use. The major significance of this program of integrated research is that it addresses many critical issues in the field of substance use (e.g., what are the risks for tobacco and drug use throughout the developmental span of childhood to adulthood; what can protect against these risks in different populations, including those implicated in the spread of AIDS; how can one break the transmission of risk from one generation to the next; and what are the factors associated with cessation of tobacco and drug use.) The K05 will enable me to devote my time and energy to research goals such as substantive and methodological development, mentoring activities (30% time), including guidance of medical students and junior faculty, and my own career development.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Award (K05)
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Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Chambers, Jessica Campbell
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New York University
Schools of Medicine
New York
United States
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Morojele, Neo K; Brook, Judith S; Brook, David W (2016) Tobacco and alcohol use among adolescents in South Africa: shared and unshared risks. J Child Adolesc Ment Health 28:139-52
Pahl, Kerstin; Brook, Judith S; Zhang, Chenshu et al. (2016) Psychosocial Predictors of Mental Health Service Utilization Among Women During their Mid-Sixties. J Behav Health Serv Res 43:143-54
Brook, Judith S; Zhang, Chenshu; Rubenstone, Elizabeth et al. (2016) Comorbid trajectories of substance use as predictors of Antisocial Personality Disorder, Major Depressive Episode, and Generalized Anxiety Disorder. Addict Behav 62:114-21
Brook, Judith S; Zhang, Chenshu; Brook, David W et al. (2015) Compulsive buying: Earlier illicit drug use, impulse buying, depression, and adult ADHD symptoms. Psychiatry Res 228:312-7
Lee, Jung Yeon; Brook, Judith S; Finch, Stephen J et al. (2015) Trajectories of marijuana use from adolescence to adulthood predicting unemployment in the mid 30s. Am J Addict 24:452-9
Brook, David W; Lee, Jung Yeon; Morojele, Neo K et al. (2015) Predictors of Childhood Depressed Mood: A Two-Generational Study. J Child Fam Stud 24:2786-2794
Brook, Judith S; Balka, Elinor B; Zhang, Chenshu et al. (2015) Intergenerational Transmission of Externalizing Behavior. J Child Fam Stud 24:2957-2965
Brook, Judith S; Zhang, Chenshu; Rubenstone, Elizabeth et al. (2015) Insomnia in adults: the impact of earlier cigarette smoking from adolescence to adulthood. J Addict Med 9:40-5
Brook, Judith S; Lee, Jung Yeon; Brook, David W (2015) Trajectories of Marijuana Use Beginning in Adolescence Predict Tobacco Dependence in Adulthood. Subst Abus 36:470-7
Brook, Judith S; Rubenstone, Elizabeth; Zhang, Chenshu et al. (2014) Better late than never: the perceived benefits of smoking cessation among women in late midlife. J Addict Dis 33:266-73

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