Abstract

Cognitive and psychological studies of patients with major psychoses are planed as part of a major effort to explore the heterogeneity of these conditions. Emphasis is given to the study of the unaffected first degree relatives of patients. Measures include smooth pursuit eye movements, quality and quantity of thought disorder, delayed response performance, anti saccade, pro saccade, and express saccade latencies. Most of these measures are also recorded in members of 5 large pedigrees in Denmark in which DNA samples are collected for chromosomal linkage analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
5K05MH001021-04
Application #
2240320
Study Section
Clinical Neuroscience Review Committee (CNR)
Project Start
1992-09-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478

  Publications

Chen, Yue; Grossman, Emily D; Bidwell, L Cinnamon et al. (2008) Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains. Cogn Affect Behav Neurosci 8:293-303
Levy, Deborah L; O'Driscoll, Gillian; Matthysse, Steven et al. (2004) Antisaccade performance in biological relatives of schizophrenia patients: a meta-analysis. Schizophr Res 71:113-25
Titone, Debra; Ditman, Tali; Holzman, Philip S et al. (2004) Transitive inference in schizophrenia: impairments in relational memory organization. Schizophr Res 68:235-47
Matthysse, Steven; Holzman, Philip S; Gusella, James F et al. (2004) Linkage of eye movement dysfunction to chromosome 6p in schizophrenia: additional evidence. Am J Med Genet B Neuropsychiatr Genet 128B:30-6
Chen, Yue; Levy, Deborah L; Sheremata, Summer et al. (2003) Effects of typical, atypical, and no antipsychotic drugs on visual contrast detection in schizophrenia. Am J Psychiatry 160:1795-801
Brownstein, Joanna; Krastoshevsky, Olga; McCollum, Courtney et al. (2003) Antisaccade performance is abnormal in schizophrenia patients but not in their biological relatives. Schizophr Res 63:13-25
Coleman, Michael J; Cook, Samantha; Matthysse, Steven et al. (2002) Spatial and object working memory impairments in schizophrenia patients: a Bayesian item-response theory analysis. J Abnorm Psychol 111:425-35
Titone, Debra; Holzman, Philip S; Levy, Deborah L (2002) Idiom processing in schizophrenia: literal implausibility saves the day for idiom priming. J Abnorm Psychol 111:313-20
Holzman, P S (2001) Seymour S. Kety and the genetics of schizophrenia. Neuropsychopharmacology 25:299-304
Kinney, D K; Levy, D L; Yurgelun-Todd, D A et al. (1999) Eye-tracking dysfunction and birth-month weather in schizophrenia. J Abnorm Psychol 108:359-62