This request for renewal of a Senior Scientist Award will support salary expenses for the principal investigator of several projects studying the psychopathology, pathophysiology, and genetics of schizophrenia. One set of studies investigates certain physiological and cognitive traits that occur more frequently among the first-degree biological relatives of schizophrenic patients than in the general population. These traits are not maladaptive in themselves, but they are useful as probes into the pathophysiology of schizophrenia, and also serve as supplementary phenotypes in chromosomal linkage analysis. Two such traits are ETD and impaired spatial working memory. The candidate is studying these two traits, using a parsing methodology as well as PET and fMRI. In addition, the candidate is continuing to gather data on patients and their first-degree family members to determine the coaggregation of these and other traits (cognitive interference, dysmorphology, and event-related potentials) in these families. The samples are drawn from McLean Hospital. Investigators from other Harvard institutions (including the Psychology and Statistics Departments of Harvard University) are centrally involved in these studies. In addition, a large linkage study, based in Denmark, in which the candidate collects eye tracking performance, thought disorder measures, and careful psychiatric diagnostic interviews, provides DNA samples, which are analyzed at the Neurogenetics Unit of the Massachusetts General Hospital.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Scientist Award (K05)
Project #
5K05MH001021-09
Application #
6185704
Study Section
Clinical Neuroscience and Biological Psychopathology Review Committee (CNBP)
Program Officer
Moldin, Steven Owen
Project Start
1992-09-01
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
9
Fiscal Year
2000
Total Cost
$104,085
Indirect Cost
Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
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