Cardiovascular diseases are posing an increasing threat to the health of older people. However, how aging impacts cardiovascular disease remains unclear. A highly collaborative environment is required to unravel the complexities of this problem. The goal of this leadership award is to develop a world-class center on aging and cardiovascular diseases at Yale School of Medicine to foster highly productive research collaborations and to educate and train the next generation of leaders in this important field. The proposed Center would be the first of its kind in the nation and will be led by Dr. Goldstein, an established physician-scientist and cardiologist who investigates how aging impacts inflammation. The Center's specific goals will be addressed in the following three aims: (1) to bring together established investigators to broadly examine how increased inflammation with aging enhances cardiovascular diseases employing both pre-clinical models and clinical material; (2) to identify highly promising fellows and junior faculty and mentor them in research areas of Aim 1, in addition to providing them pilot research funds; and (3) to develop educational forums (e.g., a specific course on topics relevant to cardiovascular aging, and an annual symposium) to disseminate key insights that translate basic mechanisms to clinical medicine. Importantly, the Center will leverage infrastructure at the Yale School of Medicine, including the Pepper Center, Center for Clinical Investigation, and Investigative Medicine program. The long-term goals of the Center will be to obtain extramural funding for multi-investigator driven proposals as well as career development faculty grants and an institutional training grant to sustain the training of postdoctoral fellows. In summary, the proposed Center will be a new initiative for Yale and will serve as a beacon of excellence for investigators pursuing research into aging and cardiovascular diseases.

Public Health Relevance

This proposal will develop a cutting edge research center at Yale to study the biological mechanisms of how aging enhances cardiovascular diseases and to train the next generation of promising investigators into the field of aging and cardiovascular disease.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Academic/Teacher Award (ATA) (K07)
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Biological Aging Review Committee (NIA-B)
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Kohanski, Ronald A
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University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
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Goldstein, Daniel R; Jalife, José (2017) Synergistic Research Between the Center of Arrhythmia Research and the Michigan Biology of Cardiovascular Aging at the University of Michigan. Circ Res 121:1221-1223
Colvin, Monica M; Smith, Candice A; Tullius, Stefan G et al. (2017) Aging and the immune response to organ transplantation. J Clin Invest 127:2523-2529
Li, Wenjun; Hsiao, Hsi-Min; Higashikubo, Ryuji et al. (2016) Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9/MyD88/CXCL5 signaling. JCI Insight 1:
Jane-Wit, Dan; Fang, Caodi; Goldstein, Daniel R (2016) Innate immune mechanisms in transplant allograft vasculopathy. Curr Opin Organ Transplant 21:253-7