Abstract

The goal under this K07 Career Award is to become an expert molecular and genetic epidemiologist, with a special focus on colorectal cancer. This goal will be accomplished by training in three interlocking areas. First, an understanding of the laboratory techniques used in genetic epidemiology studies, the underlying molecular pathology of colorectal cancer, and the clinical relevance of genetic epidemiology research will be gained through a series of independent studies, hands-on laboratory training, and attendance at appropriate seminars and conferences. Second, the epidemiology of colorectal cancer will be explored by analyzing data and specimens obtained from human subjects obtained through NCI-funded study and by correlating molecular pathologic markers with epidemiologic exposures and colorectal cancer risk. Third, the association between dietary folate intake, genetic polymorphism, and tumor methylation will be investigated in the human subjects just mentioned. Together, the training in these three areas will provide the skills and experience necessary for an independent career as a molecular and genetic epidemiologist interested in colorectal cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07CA090241-05
Application #
7101786
Study Section
Special Emphasis Panel (ZCA1-GRB-R (M3))
Program Officer
Silkensen, Shannon M
Project Start
2002-09-01
Project End
2008-02-29
Budget Start
2006-09-01
Budget End
2008-02-29
Support Year
5
Fiscal Year
2006
Total Cost
$135,900
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Lo, An-Chi; Soliman, Amr S; Khaled, Hussein M et al. (2010) Lifestyle, occupational, and reproductive factors and risk of colorectal cancer. Dis Colon Rectum 53:830-7
Lo, An-Chi; Georgopoulos, Ageliki; Kleer, Celina G et al. (2009) Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients. Breast 18:55-9
Soliman, Amr S; Banerjee, Mousumi; Lo, An-Chi et al. (2009) High proportion of inflammatory breast cancer in the Population-based Cancer Registry of Gharbiah, Egypt. Breast J 15:432-4
Lo, An-Chi; Kleer, Celina G; Banerjee, Mousumi et al. (2008) Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients. Breast Cancer Res Treat 112:141-7
Aguilar, Cristina E; Soliman, Amr S; McConnell, Daniel S et al. (2008) Androgen profiles among Egyptian adults considering liver status. J Gastroenterol Hepatol 23:e137-45
Soliman, Amr S; Lo, An-Chi; Banerjee, Mousumi et al. (2007) Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution. Carcinogenesis 28:1794-9
Lo, An-Chi; Soliman, Amr S; El-Ghawalby, Nabih et al. (2007) Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk. Pancreas 35:120-9
Kriegel, Alison M; Soliman, Amr S; Zhang, Qing et al. (2006) Serum cadmium levels in pancreatic cancer patients from the East Nile Delta region of Egypt. Environ Health Perspect 114:113-9
Soliman, Amr S; Zhang, Qing; Saleh, Thanaa et al. (2006) Pancreatic cancer mortality in Egypt: comparison to the United States pancreatic cancer mortality rates. Cancer Detect Prev 30:473-9
Shah, Namrata M; Soliman, Amr S; Benerjee, Mousumi et al. (2006) Knowledge gained after a brief CME module on breast cancer diagnosis. J Cancer Educ 21:169-74

Showing the most recent 10 out of 12 publications