The goals of this project are to develop a comprehensive and integrated teaching program in sleep physiology and sleep medicine for medical students and graduate medical trainees, and to provide measures of the success of this endeavor. At an undergraduate medical level, teaching will take place in a variety of settings starting with freshman courses in patient interviewing and lectures on sleep physiology, progressing to second year courses in pharmacology and pathophysiology, and going on to third and fourth year clerkships, a course in anesthesia/sedation and a review of clinically oriented physiology. Emphasis will be placed on the recognition and management of sleep disturbance in a primary care setting by increasing awareness of the """"""""continuity clinic."""""""" At the graduate level, a fellowship in sleep medicine will be offered, and training in sleep medicine will be integrated into the pulmonary fellowship and psychiatry and neurology residencies. Internal medicine interns are expected to become more familiar with sleep disorders by their work with the candidate in the long term care clinic. In addition to formal teaching, a goal of the graduate program will be to provide a setting in which trainees from different disciplines learn from each other. A clinically-oriented research program will be developed with emphasis on its ability both to produce high quality scientific work and provide a setting in which trainees become familiar with the close relationship of teaching, clinical care and research. Emphasis will be placed on providing high quality medical care for the inner city area served by the medical center, and on teaching community physicians through a """"""""visiting clinician"""""""" program. Effectiveness of the project will be assessed. SCIENTIFIC REVIEW ADMINISTRATOR'S NOTE Agreement to participate is needed from the individuals involved in the proposed program, and approval from the Institutional Review Board should be obtained.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
1K07HL003640-01A1
Application #
2436763
Study Section
Special Emphasis Panel (ZHL1-CCT-I (S1))
Project Start
1997-09-30
Project End
2002-08-31
Budget Start
1997-09-30
Budget End
1998-08-31
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Chicago
Department
Psychiatry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Mendelson, Wallace B; Bergmann, Bernard M; Tung, Avery (2003) Baseline and post-deprivation recovery sleep in SCN-lesioned rats. Brain Res 980:185-90
Tung, Avery; Szafran, Martin J; Bluhm, Bryan et al. (2002) Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane. Anesthesiology 97:906-11
Mendelson, Wallace B (2002) Melatonin microinjection into the medial preoptic area increases sleep in the rat. Life Sci 71:2067-70
Mendelson, W B (2001) Neurotransmitters and sleep. J Clin Psychiatry 62 Suppl 10:5-8
Mendelson, W B; Basile, A S (2001) The hypnotic actions of the fatty acid amide, oleamide. Neuropsychopharmacology 25:S36-9
Tung, A; Bluhm, B; Mendelson, W B (2001) Sleep inducing effects of propofol microinjection into the medial preoptic area are blocked by flumazenil. Brain Res 908:155-60
Mendelson, W B; Bergmann, B M (2001) Effects of pinealectomy on baseline sleep and response to sleep deprivation. Sleep 24:369-73
Laposky, A D; Homanics, G E; Basile, A et al. (2001) Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. Neuroreport 12:4143-7
Tung, A; Bluhm, B; Mendelson, W B (2001) The hypnotic effect of propofol in the medial preoptic area of the rat. Life Sci 69:855-62
Mendelson, W B (2001) The sleep-inducing effect of ethanol microinjection into the medial preoptic area is blocked by flumazenil. Brain Res 892:118-21

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