Abstract

The applicant proposes to generate two transgenic mouse models to study the genetic basis of aging. The first is the generation of telomerase (TERT) knockouts, which will then be crossed with Wrn knockouts obtained from Dr. Guarente s lab. The hypotheses are that these mice will represent models for human aging, and that the combination of both strains will generate animals with increased genomic instability.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
1K08AG001019-01
Application #
6167054
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Sierra, Felipe
Project Start
2001-09-01
Project End
2006-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
1
Fiscal Year
2001
Total Cost
$124,053
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Chang, Sandy (2005) Modeling aging and cancer in the telomerase knockout mouse. Mutat Res 576:39-53
Chang, Sandy; Khoo, Christine M; Naylor, Maria L et al. (2003) Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 17:88-100
O'Hagan, Ronan C; Chang, Sandy; Maser, Richard S et al. (2002) Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2:149-55