Abstract

The applicant proposes to generate two transgenic mouse models to study the genetic basis of aging. The first is the generation of telomerase (TERT) knockouts, which will then be crossed with Wrn knockouts obtained from Dr. Guarente s lab. The hypotheses are that these mice will represent models for human aging, and that the combination of both strains will generate animals with increased genomic instability.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08AG001019-04
Application #
6664945
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Sierra, Felipe
Project Start
2001-09-01
Project End
2004-06-30
Budget Start
2003-09-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$125,037
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Chang, Sandy (2005) Modeling aging and cancer in the telomerase knockout mouse. Mutat Res 576:39-53
Chang, Sandy; Khoo, Christine M; Naylor, Maria L et al. (2003) Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 17:88-100
O'Hagan, Ronan C; Chang, Sandy; Maser, Richard S et al. (2002) Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2:149-55