Molecular Basis of Interferon Action: Relation to M.S.

Ransohoff, Richard M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 7K08NS001265-02
• Application #: 3084127
• Study Section: Neurological Disorders Program Project Review A Committee (NSPA)
• Project Start: 1989-01-01
• Project End: 1993-02-28
• Budget Start: 1989-01-01
• Budget End: 1989-02-28
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: Cleveland Clinic Lerner
• DUNS #: 017730458
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44195

Publications

Goldstein, Larry B; Simel, David L (2005) Is this patient having a stroke? JAMA 293:2391-402

Johnston, Dean C C; Eastwood, James D; Nguyen, Thanh et al. (2002) Contrast-enhanced magnetic resonance angiography of carotid arteries: utility in routine clinical practice. Stroke 33:2834-8

Ransohoff, R M; Tuohy, V; Lehmann, P (1994) The immunology of multiple sclerosis: new intricacies and new insights. Curr Opin Neurol 7:242-9

Sen, G C; Ransohoff, R M (1993) Interferon-induced antiviral actions and their regulation. Adv Virus Res 42:57-102

Ransohoff, R M; Hamilton, T A; Tani, M et al. (1993) Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J 7:592-600

Devajyothi, C; Kalvakolanu, I; Babcock, G T et al. (1993) Inhibition of interferon-gamma-induced major histocompatibility complex class II gene transcription by interferon-beta and type beta 1 transforming growth factor in human astrocytoma cells. Definition of cis-element. J Biol Chem 268:18794-800

Johns, L D; Babcock, G; Green, D et al. (1992) Transforming growth factor-beta 1 differentially regulates proliferation and MHC class-II antigen expression in forebrain and brainstem astrocyte primary cultures. Brain Res 585:229-36

Ransohoff, R M; Devajyothi, C; Estes, M L et al. (1991) Interferon-beta specifically inhibits interferon-gamma-induced class II major histocompatibility complex gene transcription in a human astrocytoma cell line. J Neuroimmunol 33:103-12

Ransohoff, R M; Estes, M L (1991) Astrocyte expression of major histocompatibility complex gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy. Arch Neurol 48:1244-6

Meisler, D M; Tomsak, R L; Khoury, S et al. (1989) Anterior uveitis and multiple sclerosis. Cleve Clin J Med 56:535-8