Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Physician Scientist Award (K11)
Project #
5K11AR001912-04
Application #
2077464
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Ziegner, U H; Ochs, H D; Schanen, C et al. (2001) Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies. J Pediatr 138:570-3
Goldman, F D; Gilman, A L; Hollenback, C et al. (2000) Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties. Blood 95:3460-6
Rawlings, D J (1999) Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function. Clin Immunol 91:243-53
Fluckiger, A C; Sanz, E; Garcia-Lloret, M et al. (1998) In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells. Blood 92:4509-20
Fluckiger, A C; Li, Z; Kato, R M et al. (1998) Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J 17:1973-85
Rawlings, D J; Quan, S; Hao, Q L et al. (1997) Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro. Exp Hematol 25:66-72
Li, T; Rawlings, D J; Park, H et al. (1997) Constitutive membrane association potentiates activation of Bruton tyrosine kinase. Oncogene 15:1375-83
Reiff, A; Rawlings, D J; Shaham, B et al. (1997) Preliminary evidence for cyclosporin A as an alternative in the treatment of recalcitrant juvenile rheumatoid arthritis and juvenile dermatomyositis. J Rheumatol 24:2436-43
Wahl, M I; Fluckiger, A C; Kato, R M et al. (1997) Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors. Proc Natl Acad Sci U S A 94:11526-33
Rawlings, D J; Scharenberg, A M; Park, H et al. (1996) Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822-5

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