This Program Physician Scientist Award (PPSA) application seeks to provide postdoctoral research experience and scholarly research training of pediatrician-scientists in molecular biology, protein chemistry,l cell biology or other basic disciplines so as to render Trainees independent investigators making substantive contributions to biomedical research. The principal features of the program ae: [1] emphasis on the training of pediatric physician-scientists; [2] inclusion of MD-PhD's who require scientific retraining as well as MD's; [3] individually designed clinical and research training program; [4] accessibility to wide range of research laboratories in Boston biomedical community; [5] commitment to continue training even if Trainee initially unsuccessful; and [6] expectation that Trainee will join Harvard Medical School Faculty in tenure track position. Trainees will be recruited from the Hematology/Oncology and Nephrology division Fellows and from Fellows doing combined fellowships with these two divisions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
3K12DK001977-05S3
Application #
2601338
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1990-07-01
Project End
1998-06-30
Budget Start
1997-07-15
Budget End
1998-06-30
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Liu, J; Barnett, A; Neufeld, E J et al. (1999) Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. Mol Cell Biol 19:4918-26
Zund, G; Nelson, D P; Neufeld, E J et al. (1996) Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci U S A 93:7075-80
Burns, S A; Newburger, J W; Xiao, M et al. (1995) Induction of interleukin-8 messenger RNA in heart and skeletal muscle during pediatric cardiopulmonary bypass. Circulation 92:II315-21
Lievens, P M; Donady, J J; Tufarelli, C et al. (1995) Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells. J Biol Chem 270:12745-50
Burns, S A; DeGuzman, B J; Newburger, J W et al. (1995) P-selectin expression in myocardium of children undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 110:924-33
Kilbridge, P M; Mayer, J E; Newburger, J W et al. (1994) Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 107:1183-92
Guay-Woodford, L M; Bruns, G A; D'Eustachio, P (1994) Identification of a simple sequence polymorphism within the mouse locus D12Nyu2. Mamm Genome 5:251-2
Simon, E A; Cook, S; Davisson, M T et al. (1994) The mouse congenital polycystic kidney (cpk) locus maps within 1.3 cM of the chromosome 12 marker D12Nyu2. Genomics 21:415-8