In order to increase the transfer of knowledge from basic science studies into clinical applications that will improve the health of children, we propose to maintain a Child Hearth Research Center within the Department of Pediatrics. The major focus of the CHRCDA will be to train young pediatricians in the molecular biology of diseases of childhood with an emphasis on translating their experimental findings into improved healthcare for children. The CHRCDA will focus on four areas of biomedical research: (1) genetics and developmental biology, (2) pulmonary diseases associated with lung injury, (3) diseases of the hematopoietic system, and (4) infectious diseases, including the use of microbes as vectors of gene delivery. We have successfully trained independent pediatric investigators utilizing the resources provided by the previous CHRCDA and offer an outstanding group of experienced CRHC mentors and the institutional support from UAB and the Department of Pediatrics. In this application, we will build on our previous experience and modify our training program to include intensive studies in contemporary clinical research as well as formal introductions to experimental approaches employing genomic and proteomic technologies and bioinformatic systems. Our goal is to enhance the mentored research experience with a foundation of research techniques and approaches. We believe that this training program will produce the most competitive young investigators and foster the development of independent research careers.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Physician Scientist Award (Program) (PSA) (K12)
Project #
5K12HD043397-03
Application #
6844721
Study Section
Special Emphasis Panel (ZHD1-DSR-A (19))
Program Officer
Winer, Karen
Project Start
2003-04-11
Project End
2007-11-30
Budget Start
2004-12-01
Budget End
2005-11-30
Support Year
3
Fiscal Year
2005
Total Cost
$293,230
Indirect Cost
Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Harris, William T; Boyd, J Todd; McPhail, Gary L et al. (2016) Constrictive Bronchiolitis in Cystic Fibrosis Adolescents with Refractory Pulmonary Decline. Ann Am Thorac Soc 13:2174-2183
Hanks, Lynae J; GutiƩrrez, Orlando M; Ashraf, Ambika P et al. (2015) Bone Mineral Content as a Driver of Energy Expenditure in Prepubertal and Early Pubertal Boys. J Pediatr 166:1397-403
Ashraf, Ambika P; Alvarez, Jessica A; Dudenbostel, Tanja et al. (2014) Associations between vascular health indices and serum total, free and bioavailable 25-hydroxyvitamin D in adolescents. PLoS One 9:e114689
Ashraf, Ambika P; Huisingh, Carrie; Alvarez, Jessica A et al. (2014) Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J Clin Endocrinol Metab 99:178-83
Hanks, Lynae J; Ashraf, Ambika P; Gower, Barbara A et al. (2013) Subclinical Indication of Linkage Between Markers of Skeletal and Cardiovascular Properties. Bone Res 1:
Ashraf, Ambika P; Alvarez, Jessica; Huisingh, Carrie et al. (2013) Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents. Br J Med Med Res 3:1050-1061
Bhaumik, Suniti; Giffon, Thierry; Bolinger, Derek et al. (2013) Retinoic acid hypersensitivity promotes peripheral tolerance in recent thymic emigrants. J Immunol 190:2603-13
Ashraf, Ambika P; Fisher, Gordon; Alvarez, Jessica et al. (2012) Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults. J Nutr Metab 2012:475975
Hanks, L J; Casazza, K; Ashraf, A et al. (2012) Calcium homeostasis may influence resting energy expenditure with effects most apparent in early pubertal girls. Acta Paediatr 101:e363-8
Ashraf, Ambika P; Alvarez, Jessica A; Gower, Barbara A et al. (2011) Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females. Obesity (Silver Spring) 19:2214-21

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