The SDAC research plan has two parts: 1. Assessment Study. We plan to study the prevalence and patterns of drug abuse in 360 chronic mentally ill (CMI) individuals by using a comprehensive drug abuse assessment battery. 180 of the CMI are already enrolled in a 7 year prospective psychiatric study which has collected a wealth of data, but not on drug abuse. The other 180 CMI are seeking substance abuse treatment. This study will describe the association of drug abuse and sociodemographics, psychopathology, family history, and clinical course. 2. Treatment Study. We plan to assess the efficacy of innovative treatment approaches for schizophrenic cocaine abusers, including a double blind pharmacotherapy trial comparing adjunctive desipramine versus placebo in the context of a comprehensive treatment program.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Unknown (K20)
Project #
5K20DA000193-05
Application #
2443373
Study Section
Drug Abuse Epidemiology and Prevention Research Review Committee (DAPA)
Project Start
1993-07-01
Project End
1999-02-28
Budget Start
1997-07-01
Budget End
1999-02-28
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kosten, T R; Ziedonis, D M (1997) Substance abuse and schizophrenia: editors' introduction. Schizophr Bull 23:181-6