The overall goal of this Mentored, Patient-Oriented Research Career Development Award (K23) proposal is to enable Dr. McDevitt-Murphy to develop her career as a clinical scientist with a program of research in the development and evaluation of psychosocial interventions for co-occurring alcohol use disorders (AUD) and posttraumatic stress disorder (PTSD). Specifically, she will focus on AUD-PTSD among veterans recently returned from deployments to overseas conflicts, a population at high risk for AUD-PTSD. Returning veterans with AUD-PTSD would likely benefit from a cognitive-behavioral skills-based treatment focused on both PTSD symptoms and alcohol abuse, with involvement by significant others/family members. To accomplish the goal of becoming an independent researcher pursuing this line of research, the candidate would use the 5-year K23 award to pursue a training plan and to conduct a pilot study with mentorship from experts in the field. The training plan is designed to meet the following objectives: 1) Develop expertise in the design and conduct of clinical trials, particularly as they relate to psychosocial interventions research;2) Develop expertise in research on AUD treatment;3) Develop expertise in research on interventions involving family or significant others;4) Enhance knowledge and skills related to PTSD research;5) Improve understanding of methodology and statistical analyses relevant to clinical trials;6) Acquire further training in the responsible conduct of research;7) Improve grant writing and manuscript preparation skills. Dr. McDevitt-Murphy will also conduct a 5-year research project designed to develop and pilot test a cognitive-behavioral skills based intervention for comorbid AUD-PTSD that includes involvement by family members/ significant others. During the first 24 months of the award, Dr. McDevitt-Murphy will develop the manual and test it in an open trial of 15 patients. Subsequently, Dr. McDevitt-Murphy will conduct a small, randomized trial comparing the experimental treatment to an individual coping skills treatment for AUD. These data will be collected to estimate an effect size so that a larger trial may be planned. Dr. McDevitt-Murphy will submit an R01 application in year 4 of this award to obtain funding for a full-scale clinical trial. The training and research plans will be carried out under the mentorship of Drs. M. Trade Shea, Peter M. Monti, Ivan W. Miller, and Caron Zlotnick, all faculty members at Brown University.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Mentored Patient-Oriented Research Career Development Award (K23)
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Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Roach, Deidra
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University of Memphis
Schools of Arts and Sciences
United States
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Luciano, Matthew T; McDevitt-Murphy, Meghan E; Acuff, Samuel F et al. (2018) Posttraumatic stress disorder symptoms improve after an integrated brief alcohol intervention for OEF/OIF/OND veterans. Psychol Trauma :
Williams, Joah L; McDevitt-Murphy, Meghan E; Murphy, James G et al. (2017) Postconcussive Symptoms, PTSD, and Medical Disease Burden in Treatment-Seeking OEF/OIF/OND Veterans. Mil Med 182:e1645-e1650
Luciano, Matthew T; McDevitt-Murphy, Meghan E (2017) Posttraumatic Stress and Physical Health Functioning: Moderating Effects of Deployment and Postdeployment Social Support in OEF/OIF/OND Veterans. J Nerv Ment Dis 205:93-98
McDevitt-Murphy, Meghan E; Luciano, Matthew T; Tripp, Jessica C et al. (2017) Drinking motives and PTSD-related alcohol expectancies among combat veterans. Addict Behav 64:217-222
Tripp, Jessica C; McDevitt-Murphy, Meghan E (2017) Trauma-Related Guilt Mediates the Relationship between Posttraumatic Stress Disorder and Suicidal Ideation in OEF/OIF/OND Veterans. Suicide Life Threat Behav 47:78-85
R Eddinger, Jasmine; E McDevitt-Murphy, Meghan (2017) A confirmatory factor analysis of the PTSD checklist 5 in veteran and college student samples. Psychiatry Res 255:219-224
Dennhardt, Ashley A; Murphy, James G; McDevitt-Murphy, Meghan E et al. (2016) Drinking motives mediate the relationship between alcohol reward value and alcohol problems in military veterans. Psychol Addict Behav 30:819-826
Tripp, Jessica C; McDevitt-Murphy, Meghan E; Henschel, Aisling V (2016) Firing a weapon and killing in combat are associated with suicidal ideation in OEF/OIF veterans. Psychol Trauma 8:626-33
Tripp, Jessica C; McDevitt-Murphy, Meghan E (2015) Emotion dysregulation facets as mediators of the relationship between PTSD and alcohol misuse. Addict Behav 47:55-60
Tripp, Jessica C; McDevitt-Murphy, Meghan E; Avery, Megan L et al. (2015) PTSD Symptoms, Emotion Dysregulation, and Alcohol-Related Consequences Among College Students With a Trauma History. J Dual Diagn 11:107-17

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