? Candidate: The candidate received her M.D. and M.P.H. from Columbia University, performed her internal medicine residency at the University of California, San Francisco, and completed a Robert Wood Johnson Clinical Scholars fellowship in health services research. She currently practices women's health care in Obstetrics & Gynecology, and she is interested in a research career improving the quality of care for women with glucose intolerance. Sponsor and Environment: William Herman, M.D. M.P.H., a diabetologist and the Michigan Diabetes Research and Training Director, has trained numerous investigators in the field of diabetes epidemiology and health services. Dr. Herman is PI of the Translating Research Into Action for Diabetes (TRIAD) Study, which examines the quality of diabetes care. He is quite familiar with the research methods proposed in this project and will oversee Dr. Kim's formal education. Research: The long-term goal of this proposal is to improve the quality of care for women with glucose intolerance, particularly women with gestational diabetes (GDM), or glucose intolerance first recognized during pregnancy. Twenty percent of women with GDM develop type 2 diabetes (DM) within 5 years after delivery. It is unknown if modest prevention strategies would be effective in women with GDM to prevent DM. First, Dr. Kim will examine the current quality of care for women with a history of GDM. Specifically, she will examine the counseling given for DM prevention and available resources for DM prevention, and correlation with patient and physician characteristics. This study will use a cross-sectional design, consisting of women with a history of GDM (n=400). Information will be obtained primarily from patient and physician surveys. This study will use the infrastructure of the TRIAD study for subject identification, data collection, and analysis. The candidate will then conduct a pilot study randomizing women with GDM to usual care vs. an intervention (group- or telephone support) (n=100). We will adapt existing interventions to women with GDM, and preliminary focus group work will further refine the interventions. A key component is their feasibility in general practice. The pilot will generate sample size estimates for a future trial, whose main outcome will be reduced incidence of DM. These projects address the growing incidence of GDM, which is increasing due to advancing maternal age and obesity, as well as the increasing rates of DM, a major public health problem. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DK071552-03
Application #
7422276
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
2006-07-01
Project End
2011-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
3
Fiscal Year
2008
Total Cost
$134,730
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Kim, Catherine; Randolph, John F; Golden, Sherita H et al. (2015) Weight loss increases follicle stimulating hormone in overweight postmenopausal women [corrected]. Obesity (Silver Spring) 23:228-33
Kim, Catherine; Kim, Shin Y; Sappenfield, William et al. (2014) Are gestational diabetes mellitus and preconception diabetes mellitus less common in non-Hispanic black women than in non-Hispanic white women? Matern Child Health J 18:698-706
Kim, Catherine; Golden, Sherita H; Kong, Shengchun et al. (2014) Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program? Menopause 21:477-83
Buschur, Elizabeth; Sarma, Aruna V; Pietropaolo, Massimo et al. (2014) Self-reported autoimmune disease by sex in the diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC) study. Diabetes Care 37:e28-9
Kim, Catherine; Barrett-Connor, Elizabeth; Randolph, John F et al. (2014) Sex steroid levels and response to weight loss interventions among postmenopausal women in the diabetes prevention program. Obesity (Silver Spring) 22:882-7
Golden, Sherita Hill; Kim, Catherine; Barrett-Connor, Elizabeth et al. (2013) The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program. Metabolism 62:1313-22
Kim, Catherine; Kong, Shengchun; Laughlin, Gail A et al. (2013) Reductions in glucose among postmenopausal women who use and do not use estrogen therapy. Menopause 20:393-400
Kim, C; Harlow, S D; Karvonen-Gutierrez, C A et al. (2013) Racial/ethnic differences in hepatic steatosis in a population-based cohort of post-menopausal women: the Michigan Study of Women's Health Across the Nation. Diabet Med 30:1433-41
Kim, Catherine; Pi-Sunyer, Xavier; Barrett-Connor, Elizabeth et al. (2013) Sex hormone binding globulin and sex steroids among premenopausal women in the diabetes prevention program. J Clin Endocrinol Metab 98:3049-57
Kim, Catherine; Kong, Shengchun; Laughlin, Gail A et al. (2012) Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program. J Clin Endocrinol Metab 97:2853-61

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