This application proposes a research project and training plan to develop Beau B. Bruce, M.D. into an independent clinician-scientist in the area of acute neuro-ophthalmic disease. This proposal is a logical extension of Dr. Bruce's excellent academic background and early scientific efforts in the field of acute neuroophthalmic disorders, and is the next step toward gaining the experience and training that he needs to establish a successful independent clinical research career. His mentorship team will consist of David W. Wright, M.D. (co-mentor), Nancy J. Newman, M.D. (co-mentor), Roy W. Beck, M.D., Ph.D. (advisory committee), Val?rie Biousse, M.D. (advisory committee), and Michael Lynn, M.S. (advisory committee) who have exceptional experience in a variety of overlapping areas that will provide synergistic guidance and support. Emory University provides an unrivaled environment for his short- and long-term career development. He will receive training through formal course work and structured mentorship in five major areas: (1) fundamentals of clinical research, (2) practicalities of multidisciplinary, multicenter clinical trials, (3) clinical interpretation of fundus photography, (4) advanced correlated/longitudinal data analysis, and (5) telemedicine. Dr. Bruce's research protocol recognizes that there is a critical disconnect between the diagnosis and treatment of acute neuro-ophthalmic diseases within existing clinical frameworks and seeks to explore the application of emerging telemedical technologies to close this gap in clinical practice and clinical research while advancing our knowledge of these emergent diseases. It will begin to address these issues through two specific aims: (1) assessing the impact and diagnostic capability of non-dilated ocular fundus photography on the diagnosis of papilledema among headache patients presenting to the emergency department, and (2) determining risk factors among headache patients predictive for the presence of papilledema and for poor visual outcomes from papilledema. Accomplishing these aims will likely provide a new approach to the diagnosis of papilledema and improve our prognostic capability and pathophysiologic understanding of papilledema. The successful completion of this research proposal and training plan will serve as the scientific foundation for Dr. Bruce's independent clinical research career in which he seeks to advance neuro-ophthalmic scientific knowledge, facilitate patient care, and execute clinical trials of promising therapies in the field of acute neuro-ophthalmic diseases.

Public Health Relevance

This research will lead to improved diagnosis and earlier treatment of patients who go to the emergency room with headache. Using a camera that does not require dilation of the pupils, we will examine patients for swelling of the optic nerves (the cables that connect the eyes to the brain), which tells doctors that there may be a dangerous cause for the headache. In addition, because the pictures can be transmitted electronically, this will allow physicians to consult with specialists who are not immediately available, allowing for better patient care and improved research for these conditions.

National Institute of Health (NIH)
National Eye Institute (NEI)
Mentored Patient-Oriented Research Career Development Award (K23)
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Special Emphasis Panel (ZEY1-VSN (10))
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Agarwal, Neeraj
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Emory University
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Bidot, Samuel; Clough, Lindsay; Saindane, Amit M et al. (2016) The Optic Canal Size Is Associated With the Severity of Papilledema and Poor Visual Function in Idiopathic Intracranial Hypertension. J Neuroophthalmol 36:120-5
Fisayo, Adeniyi; Bruce, Beau B; Newman, Nancy J et al. (2016) Overdiagnosis of idiopathic intracranial hypertension. Neurology 86:341-50
Peragallo, Jason H; Bitrian, Elena; Kupersmith, Mark J et al. (2016) Relationship Between Age, Gender, and Race in Patients Presenting With Myasthenia Gravis With Only Ocular Manifestations. J Neuroophthalmol 36:29-32
Hage, Rabih; Eshraghi, Sheila R; Oyesiku, Nelson M et al. (2016) Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy. World Neurosurg 94:447-452
Sitko, Kevin R; Peragallo, Jason H; Bidot, Samuel et al. (2016) Pitfalls in the Use of Stereoacuity in the Diagnosis of Nonorganic Visual Loss. Ophthalmology 123:198-202
Bidot, Samuel; Bruce, Beau B (2015) Update on the Diagnosis and Treatment of Idiopathic Intracranial Hypertension. Semin Neurol 35:527-38
Digre, Kathleen B; Bruce, Beau B; McDermott, Michael P et al. (2015) Quality of life in idiopathic intracranial hypertension at diagnosis: IIH Treatment Trial results. Neurology 84:2449-56
Bruce, Beau B; Biousse, Valérie; Newman, Nancy J (2015) Nonmydriatic ocular fundus photography in neurologic emergencies. JAMA Neurol 72:455-9
Bidot, Samuel; Bruce, Beau B; Saindane, Amit M et al. (2015) Asymmetric papilledema in idiopathic intracranial hypertension. J Neuroophthalmol 35:31-6
Bidot, Samuel; Bruce, Beau B; Saindane, Amit M et al. (2015) Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Response. J Neuroophthalmol 35:331

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