The proposed K23 application will strongly support Dr. Raeanne Moore?s long-term career goal of becoming an independent clinical scientist investigating and promoting optimal functioning among older HIV+ adults, with applied expertise in using innovative mobile health technologies. The proposal has considerable

Public Health Relevance

because 1) the older HIV+ population is growing, 2) daily functioning difficulties are common among older persons living with HIV, and 3) disability costs associated with these impairments place a significant burden on society. Available assessment methods do not capture the combination of risk and protective factors impacting daily functioning, [nor do they assess day-to-day variability in daily functioning], at the intersection of HIV and aging. Ecological Momentary Assessment (EMA) via smartphones is a cost-effective, ambulatory data collection technique that allows for real-time, in vivo assessment of relationships between daily life experiences, thoughts, feelings, and behaviors. Preliminary work by the candidate demonstrated the feasibility and acceptability of smartphone-based EMA methods in older HIV+ adults. [The targeted research project aims to use EMA to: 1) accurately identify the kinds of daily activities older HIV+ adults engage in and how they appraise their success in these activities, 2) identify which patients are at the greatest risk for poor functioning (e.g., those with poorest cognition), which will help us identify patients with the greatest need for clinical services, and 3) test psychological mechanisms (e.g., depressed mood) that might be driving daily fluctuations in functioning. Results of this project will enrich our knowledge of the challenges faced by older adults with HIV and set the stage for Dr. Moore to develop mobile treatments that anticipate individual downward trajectories of daily functioning. This project is directly relevant to NIMH Strategic Objective #4 of using mobile technology to strengthen the public health impact of NIMH-supported research.] Mentored research will be supplemented with structured career development activities. These activities will fill a critical gap in Dr. Moore?s past training by enabling her to achieve the following career goals: 1) acquire key neuroAIDS knowledge [(i.e., neurocognitive, neuromedical, and psychiatric aspects of aging with HIV)]; 2) acquire expertise in EMA methodology and data analysis; 3) gain research skills in [personalized mobile intervention trial design and analysis;] and 4) enhance her professional development skills to design and conduct high-impact studies on the integration of topics in goals 1-3. To facilitate the successful completion of her training objectives and career goals, Dr. Moore has assembled an accomplished, multidisciplinary mentoring team with specific project-relevant expertise, including: assessment and intervention studies with HIV+ persons using mobile technology (Primary Mentor, David J. Moore); EMA and mobile interventions among older adults (Co-Mentor, Colin A. Depp); [advanced longitudinal biostatistics (Co-Mentor, Florin Vaida)]; neuromedical aspects of aging with HIV and clinical outcomes (Co-Mentor, Scott L. Letendre); [mobile health (mHealth) ethics (Consultant, Camille Nebeker)]; cutting-edge advances in mobile health technology (Consultant, Kevin Patrick); neuropsychology and functional outcomes in HIV (Consultant, Robert K. Heaton); and psychosocial clinical trials and real-time mobile interventions (Consultant, Eric Granholm). This proposal will capitalize on the University of California, San Diego infrastructure, including the HIV Neurobehavioral Research Program (HRNP), Stein Institute for Research on Aging, Center for Wireless and Population Health Systems, and Clinical and Translational Research Institute. The proposed hands-on research training, strong mentorship team, robust infrastructure, coursework, didactics, and scholarly activities, along with her past research and clinical experiences, will place Dr. Moore in a unique position to conduct high impact research to serve the [functional rehabilitation] needs of a growing, underserved and vulnerable population of older persons living with HIV.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Mentored Patient-Oriented Research Career Development Award (K23)
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Application #
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Brouwers, Pim
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University of California, San Diego
Schools of Medicine
La Jolla
United States
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Moore, Raeanne C; Hussain, Mariam A; Watson, Caitlin W-M et al. (2018) Grit and Ambition are Associated with Better Neurocognitive and Everyday Functioning Among Adults Living with HIV. AIDS Behav 22:3214-3225
Sundermann, Erin E; Heaton, Robert K; Pasipanodya, Elizabeth et al. (2018) Sex differences in HIV-associated cognitive impairment: an observational cohort study. AIDS :
Paolillo, Emily W; Obermeit, Lisa C; Tang, Bin et al. (2018) Smartphone-based ecological momentary assessment (EMA) of alcohol and cannabis use in older adults with and without HIV infection. Addict Behav 83:102-108
Moore, David J; Fazeli, Pariya L; Moore, Raeanne C et al. (2018) Positive Psychological Factors are Linked to Successful Cognitive Aging Among Older Persons Living with HIV/AIDS. AIDS Behav 22:1551-1561
Oppenheim, Hannah; Paolillo, Emily W; Moore, Raeanne C et al. (2018) Neurocognitive functioning predicts frailty index in HIV. Neurology 91:e162-e170
Paolillo, Emily W; Tang, Bin; Depp, Colin A et al. (2018) Temporal Associations Between Social Activity and Mood, Fatigue, and Pain in Older Adults With HIV: An Ecological Momentary Assessment Study. JMIR Ment Health 5:e38
Moore, Raeanne C; Swendsen, Joel; Depp, Colin A (2017) Applications for self-administered mobile cognitive assessments in clinical research: A systematic review. Int J Methods Psychiatr Res 26:
Moore, Raeanne C; Paolillo, Emily W; Heaton, Anne et al. (2017) Clinical utility of the UCSD Performance-Based Skills Assessment-Brief (UPSA-B) in adults living with HIV: Associations with neuropsychological impairment and patient-reported everyday functioning difficulties. PLoS One 12:e0183614
Kaufmann, Christopher N; Orff, Henry J; Moore, Raeanne C et al. (2017) Psychometric Characteristics of the Insomnia Severity Index in Veterans With History of Traumatic Brain Injury. Behav Sleep Med :1-9
Fazeli, P L; Casaletto, K B; Paolillo, E et al. (2017) Screening for neurocognitive impairment in HIV-positive adults aged 50 years and older: Montreal Cognitive Assessment relates to self-reported and clinician-rated everyday functioning. J Clin Exp Neuropsychol 39:842-853

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