The CAP candidate is a pediatrician with medical subspecialty training in nutrition, training in clinical epidemiology, and a long-standing interest in clinical research. The complementary and interdisciplinary nature of the training component of the proposed CAP program will enable him to become an independent and productive, patient-oriented researcher. The CAP candidate will be mentored for this clinical research training by Dr. Virginia A. Stallings, Chief of the Nutrition Section at the Children's CHOP, and will acquire proficiency with the techniques for the assessment of body composition, growth and energy balance. Drs. Babette S. Zemel at CHOP, and Michael I. Goran at the University of Southern California will serve as co-mentors for some aspects of this training. The candidate will also continue his advanced training in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania, leading to a Ph.D. in clinical epidemiology. The research component of the program proposes a three-year prospective cohort study aimed at investigating the components of energy balance in children with DS, to identify the causes of their increased risk for obesity. As the life expectancy of people with DS has increased, chronic diseases and the psychosocial burden associated with obesity have a significant impact on their quality of life. The primary hypothesis is that the resting energy expenditure (REE) of children with DS, measured by indirect calorimetry, is lower than the REE of healthy control subjects sharing the same family background, their siblings. The association between REE and the accretion of fat mass over a three-year follow-up period, as well as the impact of physical activity will also be investigated. REE, growth, and body composition will be measured by state of the art technologies available at the GCRC Nutrition Assessment Core Laboratory, and physical activity will be derived from measurement of total energy expenditure measured by doubly labeled water. This study will contribute to the understanding of the development of obesity in DS, and lead to clinical trials for its prevention and treatment. Furthermore, this study of children with DS is likely to provide a model of the development of obesity applicable to other children at risk, and may lead to the assessment of gene expression in DS responsible for changes in energy balance and the development of obesity.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23RR016073-05
Application #
6901941
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Wilde, David B
Project Start
2001-07-01
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2007-06-30
Support Year
5
Fiscal Year
2005
Total Cost
$112,131
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Sugiyama, Takehiro; Xie, Dawei; Graham-Maar, Rose C et al. (2007) Dietary and lifestyle factors associated with blood pressure among U.S. adolescents. J Adolesc Health 40:166-72
Stettler, Nicolas; Zomorrodi, Arezoo; Posner, Jill C (2007) Predictive value of weight-for-age to identify overweight children. Obesity (Silver Spring) 15:3106-12
Stettler, Nicolas (2007) Commentary: Growing up optimally in societies undergoing the nutritional transition, public health and research challenges. Int J Epidemiol 36:558-9

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