The goals of this K24 proposal are to train physician scientists in the conduct of patient -oriented research in Haiti and in Tanzania and to conduct a new study on urine metabolites for tuberculosis diagnosis in HIV- infected adults in Haiti (Aim 1). The training also leverages four currently funded projects in Haiti (Aims 2 - 4) and two funded projects in Mwanza, Tanzania (Aims 5-6). United States trainees will spend ~60% of their time at international research sites in Haiti or Tanzania, which have on-site Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. The common theme is that all the projects have patient-oriented research on AIDS and TB as the focus and will serve as vehicles for mentored research training. The projects include: 1. Urine metabolites for the diagnosis of TB in HIV-infected adults in Haiti 2. Translational studies of TB latency, persistence, and antituberculous drugs 3. A randomized trial of cohort care for HIV infected adolescent girls 4. HIV therapeutic clinical trials in adults, adolescents, and children 5. Female genital schistosomiasis and HIV interactions 6. The epidemiology of HIV related cardiovascular disease The focus of research-training will be on physician-scientists who have completed their clinical training. Dr. Fitzgerald serves in a leadership role on two Weill-Cornell fellowship programs: the Global Health Research Fellowship in General Internal Medicine and the T32 training program for Infectious Diseases Fellows. Trainees from these programs will be mentored by Dr. Fitzgerald and will participate in research projects in Haiti (Aims 1-4) or Tanzania (5-6). These six projects have both clinical and laboratory aspects and offer trainees broad research experience. Trainees learn through the conduct of their mentored research project and the opportunity to interact with colleagues working on studies other than their own.

Public Health Relevance

The goals of this K24 proposal are to train physician scientists in the conduct of patient - oriented research in Haiti and in Tanzania and to conduct a new study on urine biomarkers for tuberculosis diagnosis in HIV-infected adults in Haiti. United States trainees will spend ~60% of their time at international research sites in Haiti or Tanzania, which have on-site Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. All the projects have patient-oriented research on AIDS and TB as their focus with both clinical and laboratory aspects and offer trainees broad experience through the conduct of a mentored research project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24AI098627-06
Application #
9559768
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Huebner, Robin E
Project Start
2012-04-01
Project End
2023-01-31
Budget Start
2018-02-19
Budget End
2019-01-31
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
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Isa, Flonza; Collins, Sean; Lee, Myung Hee et al. (2018) Mass Spectrometric Identification of Urinary Biomarkers of Pulmonary Tuberculosis. EBioMedicine 31:157-165
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Batavia, Ashita S; Severe, Patrice; Lee, Myung Hee et al. (2018) Blood pressure and mortality in a prospective cohort of HIV-infected adults in Port-au-Prince, Haiti. J Hypertens 36:1533-1539
Kidenya, Benson R; Mshana, Stephen E; Fitzgerald, Daniel W et al. (2018) Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania. Tuberculosis (Edinb) 109:97-101
McAulay, Kathrine; Saito, Kohta; Warrier, Thulasi et al. (2018) Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment. MBio 9:
Reif, L K; Rivera, V; Bertrand, R et al. (2018) Outcomes across the tuberculosis care continuum among adolescents in Haiti. Public Health Action 8:103-109

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