This is a proposed K24 award for Dr. Frederick Hecht, Professor of Medicine at the University of California (UCSF), and director of research at the UCSF Osher Center for Integrative Medicine. Dr. Hecht is an internist with postdoctoral training in clinical epidemiology. He is director of the T32-funded UCSF Training in Research in Integrative Medicine (TRIM) fellowship program, and principal investigator of an NCCAM funded Center for Excellence in CAM Research PO1 investigating the metabolic and immunologic effects of meditation. He has mentored more than 25 postdoctoral fellows and junior faculty and published over 130 peer-reviewed articles. With this K24, Dr.
Hecht aims to mentor four postdoctoral and two predoctoral fellows in the TRIM program each year, serving as primary mentor for half. He will mentor a regular panel of five to seven junior faculty with K awards. He will develop his research and mentoring capabilities with advanced seminars on research design and biostatistics. He has assembled an outstanding team to mentor the mentor in specific areas and provide additional enrichment for trainees, including Dr. Peter Bacchetti, director of the UCSF Biostatistics Consult service, and Dr. Bernard Lo, former director of the UCSF Program in Medical Ethics. UCSF provides an extremely rich and supportive scientific environment for Dr. Hecht's research and that of his mentees; including the second largest NIH funded CTSA, which is closely integrated with Dr. Hecht's K24 plans. The specific research aims of Dr. Hecht's research program are:
Aim 1 : Test the health benefits of mind-body interventions.
Aim 2 : Apply innovative approaches to test the mechanisms of action of integrative medicine therapies.
Aim 3 : Develop and test new models of integrative medicine approaches to lifestyle interventions.
Aim 4 : Develop models of integrative medicine research in medically underserved settings. Overall, Dr. Hecht's research program aims to bring integrative medicine approaches to bear on some of our most important chronic health problems, including obesity, diabetes, and hypertension. This K24 application aims to provide mentoring and a research environment to develop an exceptionally strong and diverse group of researchers who will play leading roles in the future of integrative medicine research.

Public Health Relevance

Integrative medicine approaches have important potential to improve treatment for some of our most important chronic health problems, including obesity, diabetes, and hypertension. This K24 application will support mentoring and a research environment to develop a new generation of researchers who can advance research on integrative medicine approaches to these important health problems.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZAT1)
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Reider, Eve
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Mason, Ashley E; Hecht, Frederick M; Daubenmier, Jennifer J et al. (2018) Weight Loss Maintenance and Cellular Aging in the Supporting Health Through Nutrition and Exercise Study. Psychosom Med 80:609-619
Batchelder, Abigail W; Carrico, Adam W; Acree, Michael et al. (2018) Positive and Negative Self-Conscious Emotion and Transmission Risk Following HIV Diagnosis. AIDS Behav 22:1496-1502
Mascarenhas, Maya Nina; Chan, June Maylin; Vittinghoff, Eric et al. (2018) Increasing Physical Activity in Mothers Using Video Exercise Groups and Exercise Mobile Apps: Randomized Controlled Trial. J Med Internet Res 20:e179
Crane, Rebecca S; Hecht, Frederick M (2018) Intervention Integrity in Mindfulness-Based Research. Mindfulness (N Y) 9:1370-1380
Saslow, Laura R; Mason, Ashley E; Kim, Sarah et al. (2017) An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial. J Med Internet Res 19:e36
Gurfein, Blake T; Hasdemir, Burcu; Milush, Jeffrey M et al. (2017) Enriched environment and stress exposure influence splenic B lymphocyte composition. PLoS One 12:e0180771
Nititham, Joanne; Gupta, Rashmi; Zeng, Xue et al. (2017) Psoriasis risk SNPs and their association with HIV-1 control. Hum Immunol 78:179-184
Saslow, Laura R; Daubenmier, Jennifer J; Moskowitz, Judith T et al. (2017) Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutr Diabetes 7:304
Adler, Elizabeth; Dhruva, Anand; Moran, Patricia J et al. (2017) Impact of a Mindfulness-Based Weight-Loss Intervention on Sleep Quality Among Adults with Obesity: Data from the SHINE Randomized Controlled Trial. J Altern Complement Med 23:188-195
Kiniry, B E; Ganesh, A; Critchfield, J W et al. (2017) Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol 10:1008-1020

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