This is a proposed renewal of a highly successful K24 award for Dr. Frederick Hecht, Professor of Medicine at the University of California (UCSF), and director of research at the UCSF Osher Center for Integrative Medicine. Dr. Hecht is an internist with postdoctoral training in clinical epidemiology, who is a leader in research on mindfulness-based interventions and health. He directs the T32-funded UCSF Training in Research in Integrative Medicine (TRIM) fellowship program, and is principal investigator for two NCCIH research grants. He has mentored more than 40 postdoctoral fellows and junior faculty and published over 200 peer-reviewed articles. In the initial K24 period, Dr. Hecht has mentored 12 pre/postdoctoral fellows and 10 junior faculty on K awards. With this K24 renewal, Dr.
Hecht aims to mentor at least four postdoctoral and two predoctoral fellows each year, and four to six junior faculty with K awards. He will further develop his research and mentoring capabilities with advanced seminars on research design and biostatistics. UCSF provides an extremely rich and supportive scientific environment for Dr. Hecht's research and that of his mentees, including an outstanding NIH funded CTSA, which is closely integrated with Dr. Hecht's K24 plans. The specific research aims of Dr. Hecht's research program are to: (1) develop and test innovative applications of mindfulness-based interventions and tools for studying the active components of these interventions, (2) assess the mechanisms of action of integrative medicine therapies, and (3) test the benefits of integrative medicine therapies such as acupuncture/acupressure and yoga in decreasing pain and improving symptom management. In this K-24 renewal, Dr. Hecht will continue to focus his research and mentoring on some of our most important chronic health problems, including obesity, pain, and diabetes, applying innovative methodological approaches such as adaptive interventions to optimize integrative medicine based interventions for treatment and prevention of these conditions. With this renewal, he aims to continue providing mentoring and a research environment to develop an exceptionally strong and diverse group of researchers who will play leading roles in the future of integrative medicine research.

Public Health Relevance

Integrative medicine approaches have important potential to improve treatment for some of our most important chronic health problems, including obesity, pain, and diabetes. This K24 proposal will support mentoring and a research environment to develop a new generation of researchers who can advance research on integrative medicine approaches to these important health problems.

National Institute of Health (NIH)
National Center for Complementary & Alternative Medicine (NCCAM)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Special Emphasis Panel (ZAT1)
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Mudd, Lanay Marie
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Mason, Ashley E; Hecht, Frederick M; Daubenmier, Jennifer J et al. (2018) Weight Loss Maintenance and Cellular Aging in the Supporting Health Through Nutrition and Exercise Study. Psychosom Med 80:609-619
Batchelder, Abigail W; Carrico, Adam W; Acree, Michael et al. (2018) Positive and Negative Self-Conscious Emotion and Transmission Risk Following HIV Diagnosis. AIDS Behav 22:1496-1502
Mascarenhas, Maya Nina; Chan, June Maylin; Vittinghoff, Eric et al. (2018) Increasing Physical Activity in Mothers Using Video Exercise Groups and Exercise Mobile Apps: Randomized Controlled Trial. J Med Internet Res 20:e179
Crane, Rebecca S; Hecht, Frederick M (2018) Intervention Integrity in Mindfulness-Based Research. Mindfulness (N Y) 9:1370-1380
Saslow, Laura R; Mason, Ashley E; Kim, Sarah et al. (2017) An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial. J Med Internet Res 19:e36
Gurfein, Blake T; Hasdemir, Burcu; Milush, Jeffrey M et al. (2017) Enriched environment and stress exposure influence splenic B lymphocyte composition. PLoS One 12:e0180771
Nititham, Joanne; Gupta, Rashmi; Zeng, Xue et al. (2017) Psoriasis risk SNPs and their association with HIV-1 control. Hum Immunol 78:179-184
Saslow, Laura R; Daubenmier, Jennifer J; Moskowitz, Judith T et al. (2017) Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutr Diabetes 7:304
Adler, Elizabeth; Dhruva, Anand; Moran, Patricia J et al. (2017) Impact of a Mindfulness-Based Weight-Loss Intervention on Sleep Quality Among Adults with Obesity: Data from the SHINE Randomized Controlled Trial. J Altern Complement Med 23:188-195
Kiniry, B E; Ganesh, A; Critchfield, J W et al. (2017) Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol 10:1008-1020

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