This K24 application has two broad goals: mentoring junior investigators in patient-oriented research and pursuing and expanding a research program in the genetics and prevention of gastrointestinal cancers. The candidate, Sapna Syngal, MD, MPH, is an Assistant Professor of Medicine at Harvard Medical School, with dual appointments in the Population Sciences Division of Dana-Farber Cancer Institute and the Gastroenterology Division at Brigham and Women's Hospital. She has established a track record at supporting and advancing the careers of physicians pursuing patient-oriented research in gastroenterology. Her current group of mentees include 14 post-doctoral fellows, all who are physicians from a variety of subspecialty backgrounds including gastroenterology, genetics, internal medicine and oncology. All mentees who have completed training with Dr. Syngal obtained a Masters in Public Health from the Harvard School of Public Health during their training period and currently hold faculty positions in academic institutions, devoting the majority of their time to pursuing patient-oriented research. Dr. Syngal is an active faculty member of a variety of NIH training grants, including a T32 in Gastroenterology, a T32 in Genetics and a R25 in Cancer Outcomes - these training grants provide salary support for the current post-doctoral fellows in Dr. Syngal's program as well as tuition costs for the MPH degree. She has been honored for mentoring by the Dana-Farber Cancer Institute Fred P Li Award for Mentoring in 2003. Dr. Syngal's research program includes evaluation of (1) screening compliance in patients at high risk for colorectal cancer;(2) the role of the mismatch repair gene, MSH6 in familial colorectal cancer;(3) the impact of genetic testing on surveillance and management of hereditary colon cancer;(4) the development of a prediction rule for mutation carriers in the MSH2 and MLH1 genes;and (5) the study of stool DMA tests and other biomarkers for early detection of colorectal cancer. Dr, Syngal is the Principal Investigator of a K07 and an RO1 award and a co-investigator on several other multi-center NIH grants. Dr. Syngal received the Young Investigator Clinical Science Award in 2004 by the American Gastroenterological Association, the, highest honor given by the AGA to one junior faculty clinical investigator nationally per year.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24CA113433-05
Application #
7663971
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
2005-08-01
Project End
2010-07-31
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
5
Fiscal Year
2009
Total Cost
$152,458
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Kastrinos, Fay; Uno, Hajime; Ukaegbu, Chinedu et al. (2017) Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome. J Clin Oncol 35:2165-2172
Yurgelun, Matthew B; Kulke, Matthew H; Fuchs, Charles S et al. (2017) Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. J Clin Oncol 35:1086-1095
Kastrinos, Fay; Ojha, Rohit P; Leenen, Celine et al. (2016) Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer. J Natl Cancer Inst 108:
Yurgelun, Matthew B; Masciari, Serena; Joshi, Victoria A et al. (2015) Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry. JAMA Oncol 1:214-21
Inra, Jennifer A; Steyerberg, Ewout W; Grover, Shilpa et al. (2015) Racial variation in frequency and phenotypes of APC and MUTYH mutations in 6,169 individuals undergoing genetic testing. Genet Med 17:815-21
Yurgelun, Matthew B; Allen, Brian; Kaldate, Rajesh R et al. (2015) Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome. Gastroenterology 149:604-13.e20
Yurgelun, Matthew B; Hornick, Jason L; Curry, Victoriana K et al. (2014) Therapy-associated polyposis as a late sequela of cancer treatment. Clin Gastroenterol Hepatol 12:1046-50
Chin, Y Rebecca; Yuan, Xin; Balk, Steven P et al. (2014) PTEN-deficient tumors depend on AKT2 for maintenance and survival. Cancer Discov 4:942-55
Ma, Tianle; Jang, Eun Jeong; Zukerberg, Lawrence R et al. (2014) Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome. Surg Endosc 28:2349-56
Everett, Jessica N; Raymond, Victoria M; Dandapani, Monica et al. (2014) Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm. JAMA Dermatol 150:1315-21

Showing the most recent 10 out of 48 publications