This application is for a Midcareer Investigator Award in Patient-Oriented Research (K24) so that over the next five years I can focus predominantly on clinical research, writing and mentoring beginning investigators. My research has been aimed at improving the accessibility, availability and efficacy of substance abuse treatment through clinical trials and clinical epidemiologic studies. The general themes of my research and approaches utilized are evident in my two major research programs, investigating pharmacologic and behavioral components of opioid agonist maintenance treatment and investigating treatments for cocaine dependent pregnant women and women with young children. Coordination and integration of substance abuse and medical services has been one important strategy explored in this research, as exemplified by current projects and clinical research planned for the proposed award period. These studies include evaluation of buprenorphine maintenance in a primary care clinic, medical maintenance for stabilized methadone maintained patients, and behavioral treatments for cocaine-dependent women identified in prenatal and pediatric clinics. The latter study is one of the major projects planned for the initial years of the proposed award and is described more fully in this application. The study is a 2X2 clinical trial comparing two manual-guided treatments, Community Reinforcement Approach (CRA) and Drug Counseling (DC) based on a 12-step model, and comparing Contingency Management (CM) using a voucher procedure to reward abstinence and a yoked, non-contingent Voucher Control (VC). For nearly a decade, I have been PI on between 2 and 4 externally funded studies at any time. I anticipate maintaining at least this level of support in the future, especially if I receive a K24 award and am thus able to be relieved of most of my now substantial clinical and administrative responsibilities. My clinical research and mentoring activities are facilitated by the extensive clinical research, teaching and clinical programs in drug abuse at Yale which also provide outstanding opportunities for recruitment of beginning investigators needing mentoring and a fertile environment for training them. I have had considerable experience training and mentoring beginning investigators and I am currently mentoring four recently appointed faculty members and one post-doctoral trainee. A K24 award would thus provide a critical opportunity for me to enhance my own clinical research career and devote more time to mentoring beginning investigators, as proposed in this application.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA000445-04
Application #
6628322
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Czechowicz, Dorynne D
Project Start
2000-02-15
Project End
2005-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
4
Fiscal Year
2003
Total Cost
$107,206
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Schottenfeld, Richard S; Chawarski, Marek C; Sofuoglu, Mehmet et al. (2018) Atomoxetine for amphetamine-type stimulant dependence during buprenorphine treatment: A randomized controlled trial. Drug Alcohol Depend 186:130-137
Kiyatkin, Eugene A; Ren, Suelynn E (2017) MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment. Curr Top Behav Neurosci 32:183-207
Barry, Declan T; Cutter, Christopher J; Beitel, Mark et al. (2016) Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. J Clin Psychiatry 77:1413-1419
Mokri, Azarakhsh; Chawarski, Marek C; Taherinakhost, Hamidreza et al. (2016) Medical treatments for opioid use disorder in Iran: a randomized, double-blind placebo-controlled comparison of buprenorphine/naloxone and naltrexone maintenance treatment. Addiction 111:874-82
Oberleitner, Lindsay M; Beitel, Mark; Schottenfeld, Richard S et al. (2016) Drug Counselors' Attitudes Toward Nonpharmacologic Treatments for Chronic Pain. J Addict Med 10:34-9
Wakabayashi, Ken T; Spekterman, Laurence; Kiyatkin, Eugene A (2016) Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain. Eur J Neurosci 43:1422-30
Marienfeld, Carla; Chawarski, Marek (2016) Teaching Psychosocial Interventions for Opioid Use Disorder in Low and Middle Income Countries: Malaysia and China. Acad Psychiatry 40:507-13
Cutter, Christopher J; Schottenfeld, Richard S; Moore, Brent A et al. (2014) A pilot trial of a videogame-based exercise program for methadone maintained patients. J Subst Abuse Treat 47:299-305
Schottenfeld, Richard S; Chawarski, Marek C; Cubells, Joseph F et al. (2014) Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. Drug Alcohol Depend 136:36-42
Barry, Declan T; Savant, Jonathan D; Beitel, Mark et al. (2014) The feasibility and acceptability of groups for pain management in methadone maintenance treatment. J Addict Med 8:338-44

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