This is a renewal application for a Midcareer Investigator Award in Patient-Oriented Research (K24). By relieving me of substantial clinical and administrative responsibilities, the K24 has allowed me to increase the level of my involvement in research aimed at improving the efficacy and accessibility of treatments for opioid and cocaine dependence, expand my research into the international arena, and increase my mentoring of beginning investigators. Current studies are investigating 1) contracting and behavioral activation therapy for methadone maintained patients with persistent depressive symptoms, 2) the pharmacogenetics of disulfiram response to cocaine during buprenorphine maintenance treatment, 3) buprenorphine maintenance in primary care settings, and 4) buprenorphine and naltrexone for treating opioid dependence in Malaysia and Iran, predominantly Muslim countries facing extreme problems of opioid dependence and the emergence of HIV. The international studies are two of the major projects planned for the initial years of the proposed K24 and described more fully in this application. Both are randomized, double blind comparisons of buprenorphine and naltrexone; the 3-cell study in Malaysia includes a placebo (drug counseling only) group. Both provide opportunities for training and mentoring beginning drug abuse researchers and developing a drug abuse clinical research infrastructure that will support future research and dissemination of evidence-based treatments in these countries. My mentoring of beginning investigators occurs in the context of the clinical trials. During the current grant period, I have served as research mentor for four beginning investigators who have succeeded in developing independent areas of research and obtaining external support for their research, and I am currently mentoring 8 investigators. My clinical research and mentoring activities are facilitated by the extensive clinical research, teaching and clinical programs in drug abuse at Yale and by the development of several international HIV and drug abuse clinical research training programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA000445-09
Application #
7492965
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Aklin, Will
Project Start
2000-02-15
Project End
2010-01-31
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
9
Fiscal Year
2008
Total Cost
$157,292
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Schottenfeld, Richard S; Chawarski, Marek C; Sofuoglu, Mehmet et al. (2018) Atomoxetine for amphetamine-type stimulant dependence during buprenorphine treatment: A randomized controlled trial. Drug Alcohol Depend 186:130-137
Kiyatkin, Eugene A; Ren, Suelynn E (2017) MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment. Curr Top Behav Neurosci 32:183-207
Barry, Declan T; Cutter, Christopher J; Beitel, Mark et al. (2016) Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. J Clin Psychiatry 77:1413-1419
Mokri, Azarakhsh; Chawarski, Marek C; Taherinakhost, Hamidreza et al. (2016) Medical treatments for opioid use disorder in Iran: a randomized, double-blind placebo-controlled comparison of buprenorphine/naloxone and naltrexone maintenance treatment. Addiction 111:874-82
Oberleitner, Lindsay M; Beitel, Mark; Schottenfeld, Richard S et al. (2016) Drug Counselors' Attitudes Toward Nonpharmacologic Treatments for Chronic Pain. J Addict Med 10:34-9
Wakabayashi, Ken T; Spekterman, Laurence; Kiyatkin, Eugene A (2016) Experience-dependent escalation of glucose drinking and the development of glucose preference over fructose - association with glucose entry into the brain. Eur J Neurosci 43:1422-30
Marienfeld, Carla; Chawarski, Marek (2016) Teaching Psychosocial Interventions for Opioid Use Disorder in Low and Middle Income Countries: Malaysia and China. Acad Psychiatry 40:507-13
Cutter, Christopher J; Schottenfeld, Richard S; Moore, Brent A et al. (2014) A pilot trial of a videogame-based exercise program for methadone maintained patients. J Subst Abuse Treat 47:299-305
Schottenfeld, Richard S; Chawarski, Marek C; Cubells, Joseph F et al. (2014) Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. Drug Alcohol Depend 136:36-42
Barry, Declan T; Savant, Jonathan D; Beitel, Mark et al. (2014) The feasibility and acceptability of groups for pain management in methadone maintenance treatment. J Addict Med 8:338-44

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