I have had the opportunity to develop a clinical research career in the overlap between addiction and infectious diseases, in particular among injection drug users, with a focus on incarcerated populations. The purpose of this application for a Midcareer Investigator Award in Patient-Oriented Research (K24) is to provide protected time that I can devote to mentor junior clinical investigators in patient-oriented research focused on critical issues related to HIV and other infectious diseases among addicted individuals. This proposal builds on the existing resources at our institution that has a robust track record of training undergraduate, graduate, post-graduate students, trainees and junior faculty to become independent investigators in multiple disciplines. My host institution is committed to research training that can prepare the next generation of physicians to bridge the gaps in our knowledge in HIV care and prevention, especially in HIV treatment and prevention in persons affected by the disease of addiction. The Division of Infectious Diseases at The Miriam Hospital, Brown Medical School, includes the NIH funded Adult AIDS Clinical Trials Unit, the Brown/Tufts/Lifespan Center for AIDS Research, the AIDS International Training and Research Program, the Center for Drug Addiction and AIDS Research, funded training grants, and the recently founded, Center for Prisoner Health and Human Rights at The Miriam Hospital. The spread of HIV through drug injection and sexual contact with injection drug users has been a leading cause of HIV since the very beginning of the epidemic in the United States, and is driving the HIV epidemic in many parts of the world. In the United States, between 20-26% of all individuals with HIV infection pass through a correctional setting each year. In the correctional setting, there exist tremendous opportunities for the diagnosis, prevention, treatment of infectious diseases, as well as linkage to medical care and substance abuse treatment. My CSAT funded, Project MOD, has demonstrated that linkage to methadone maintenance treatment at the time of release from incarceration is a very promising strategy to reduce the risks of HIV, along with recidivism and resumption of drug use. My currently funded R01 is further exploring the benefits of linkage to substance abuse treatment in this population. Both provide excellent opportunities to mentor junior colleagues in patient oriented research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA022112-05
Application #
8269109
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Biswas, Jamie
Project Start
2008-08-15
Project End
2013-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$172,085
Indirect Cost
$12,747
Name
Miriam Hospital
Department
Type
DUNS #
063902704
City
Providence
State
RI
Country
United States
Zip Code
02906
Carroll, Jennifer J; Rich, Josiah D; Green, Traci C (2018) Reducing Collateral Damage in Responses to the Opioid Crisis. Am J Public Health 108:349-350
Brinkley-Rubinstein, Lauren; Macmadu, Alexandria; Marshall, Brandon D L et al. (2018) Risk of fentanyl-involved overdose among those with past year incarceration: Findings from a recent outbreak in 2014 and 2015. Drug Alcohol Depend 185:189-191
Claborn, Kasey; Becker, Sara; Operario, Don et al. (2018) Adherence intervention for HIV-infected persons who use drugs: adaptation, open trial, and pilot randomized hybrid type 1 trial protocol. Addict Sci Clin Pract 13:12
Gordon, Michael S; Crable, Erika L; Carswell, Steven B et al. (2018) A Randomized Controlled Trial of Intensive Case Management (Project Bridge) for HIV-Infected Probationers and Parolees. AIDS Behav 22:1030-1038
Murphy, Matthew; Berns, Abby L; Bandyopadhyay, Utpala et al. (2018) Varicella in the prison setting: A report of three outbreaks in Rhode Island and a review of the literature. Vaccine 36:5651-5656
Green, Traci C; Clarke, Jennifer; Brinkley-Rubinstein, Lauren et al. (2018) Postincarceration Fatal Overdoses After Implementing Medications for Addiction Treatment in a Statewide Correctional System. JAMA Psychiatry 75:405-407
Carroll, Jennifer J; Rich, Josiah D; Green, Traci C (2018) The More Things Change: Buprenorphine/naloxone Diversion Continues While Treatment Remains Inaccessible. J Addict Med 12:459-465
Brinkley-Rubinstein, Lauren; McKenzie, Michelle; Macmadu, Alexandria et al. (2018) A randomized, open label trial of methadone continuation versus forced withdrawal in a combined US prison and jail: Findings at 12 months post-release. Drug Alcohol Depend 184:57-63
Stone, Andrew C; Carroll, Jennifer J; Rich, Josiah D et al. (2018) Methadone maintenance treatment among patients exposed to illicit fentanyl in Rhode Island: Safety, dose, retention, and relapse at 6 months. Drug Alcohol Depend 192:94-97
Krieger, Maxwell S; Yedinak, Jesse L; Buxton, Jane A et al. (2018) High willingness to use rapid fentanyl test strips among young adults who use drugs. Harm Reduct J 15:7

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