(taken from the application) We are in the midst of an epidemic of end stage renal disease (ESRD). Treated ESRD has increased exponentially at an annual rate of 8% since 1973 when the U.S. ESRD treatment registry was initiated. Although it preserves life, treated ESRD is associated with poor quality of life, considerable morbidity, and high mortality. The leading cause of death in treated ESRD patients is cardiovascular disease. The Principal Investigator is a leader in the epidemiology and prevention of renal disease who has an outstanding track record in patient-oriented research and mentorship. He has assembled and mentored a team of superb young investigators who are seeking to understand better the reasons for the increased risk of cardiovascular disease in patients with treated ESRD and less severe forms of renal disease. Mentorship is accomplished through a rigorous program of training in epidemiologic methods and intensive involvement in ongoing, federally-funded research projects. Tuition costs are covered by NIH sponsored training grants from NIDDK and NHLBI. The current proposal requests funds to increase the Principal Investigator's ability to mentor trainees and junior faculty by decreasing his substantial administrative commitment. The research projects described in this proposal are built on the foundation of the CHOICE Cohort Study, a national prospective study of over 1,000 incident cases of ESRD. A DNA and serum bank has been established at a central laboratory. Current research project conducted by trainees who will be mentored by the Principal Investigator as part of the current proposal include: 1. The role of emerging risk factors (Lpa, homocysteine, B vitamin, fibrinogen levels) in risk of CVD ESRD patients; 2. Identification of genes that increase risk of progression to ESRD; 3. Risk factors for vascular access failure. This information will lay the groundwork to prevent CVD in ESRD patients by providing the information needed for clinical trials. The Principal Investigator has a long history of successful mentoring in renal disease research. The proposed award will allow him to continue training the next generation of renal disease epidemiologists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK002856-03
Application #
6516783
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2000-07-01
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
3
Fiscal Year
2002
Total Cost
$124,667
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Armstrong, Nicole M; Meoni, Lucy A; Carlson, Michelle C et al. (2017) Cardiovascular risk factors and risk of incident depression throughout adulthood among men: The Johns Hopkins Precursors Study. J Affect Disord 214:60-66
Shihab, Hasan M; Meoni, Lucy A; Chu, Audrey Y et al. (2012) Body mass index and risk of incident hypertension over the life course: the Johns Hopkins Precursors Study. Circulation 126:2983-9
Gross, Alden L; Rebok, George W; Ford, Daniel E et al. (2011) Alcohol consumption and domain-specific cognitive function in older adults: longitudinal data from the Johns Hopkins Precursors Study. J Gerontol B Psychol Sci Soc Sci 66:39-47
Engelman, Michal; Agree, Emily M; Meoni, Lucy A et al. (2010) Propositional density and cognitive function in later life: findings from the Precursors Study. J Gerontol B Psychol Sci Soc Sci 65:706-11
Chu, Audrey Y; Meoni, Lucy A; Wang, Nae Yuh et al. (2010) Reliability of alcohol recall after 15 years and 23 years of follow-up in the Johns Hopkins Precursors Study. J Stud Alcohol Drugs 71:143-9
Parekh, Rulan S; Plantinga, Laura C; Kao, W H Linda et al. (2008) The association of sudden cardiac death with inflammation and other traditional risk factors. Kidney Int 74:1335-42
Wittink, Marsha N; Morales, Knashawn H; Meoni, Lucy A et al. (2008) Stability of preferences for end-of-life treatment after 3 years of follow-up: the Johns Hopkins Precursors Study. Arch Intern Med 168:2125-30
Wang, Nae-Yuh; Young, J Hunter; Meoni, Lucy A et al. (2008) Blood pressure change and risk of hypertension associated with parental hypertension: the Johns Hopkins Precursors Study. Arch Intern Med 168:643-8
Parekh, Rulan S; Kao, W H Linda; Meoni, Lucy A et al. (2007) Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the Family Investigation of Nephropathy and Diabetes. Clin J Am Soc Nephrol 2:1156-62
Plantinga, Laura C; Fink, Nancy E; Levin, Nathan W et al. (2007) Early, intermediate, and long-term risk factors for mortality in incident dialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study. Am J Kidney Dis 49:831-40

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