The U.S. is in the midst of an epidemic of chronic kidney disease. The incidence of treated end stage renal disease (ESRD) has risen every year since Medicare began collecting such information in 1973. In 2002, over 500,000 persons in the U.S. were treated for ESRD and about 20 million persons are estimated to have chronic kidney disease. Thus, chronic kidney disease is a major clinical and public health problem that demands our utmost attention. The present application is a renewal request for a K-24 award that the PI received in 2000. The PI is an established leader in the epidemiology and prevention of kidney disease who has an outstanding record of accomplishments in mentorship and conduct of patient-oriented research. The focus of his work has been to understand better the reasons for the excess risk of cardiovascular disease in persons with treated ESRD and milder forms of kidney disease. During the last 4 years, the PI has mentored 19 trainees and junior faculty and published 51 articles, 43 of which are peer-reviewed manuscripts, 25 of which have mentees as first author. Mentorship is accomplished through a rigorous didactic training program coupled with a mentored research experience and intensive involvement in federally-funded research projects. Training takes place within a very rich research environment and trainees are supported through institutional training grants as well as individual grants. A number of research opportunities exist for trainees;this application details a new cohort study of 1,000 treated ESRD patients from the Baltimore area who will be followed for up to 4 years to determine risk factors (traditional cardiovascular disease, dialysis-related, and genetic risk factors) for sudden cardiac death (SCD). ESRD patients are at very high risk of SCD, equivalent to persons who are post-myocardial infarction. This study will not only provide data to reduce the risk of this untoward event but will also provide a rich infrastructure for future studies, including clinical trials, and for research training.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK002856-10
Application #
7661574
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2000-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
10
Fiscal Year
2009
Total Cost
$118,674
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Armstrong, Nicole M; Meoni, Lucy A; Carlson, Michelle C et al. (2017) Cardiovascular risk factors and risk of incident depression throughout adulthood among men: The Johns Hopkins Precursors Study. J Affect Disord 214:60-66
Shihab, Hasan M; Meoni, Lucy A; Chu, Audrey Y et al. (2012) Body mass index and risk of incident hypertension over the life course: the Johns Hopkins Precursors Study. Circulation 126:2983-9
Gross, Alden L; Rebok, George W; Ford, Daniel E et al. (2011) Alcohol consumption and domain-specific cognitive function in older adults: longitudinal data from the Johns Hopkins Precursors Study. J Gerontol B Psychol Sci Soc Sci 66:39-47
Engelman, Michal; Agree, Emily M; Meoni, Lucy A et al. (2010) Propositional density and cognitive function in later life: findings from the Precursors Study. J Gerontol B Psychol Sci Soc Sci 65:706-11
Chu, Audrey Y; Meoni, Lucy A; Wang, Nae Yuh et al. (2010) Reliability of alcohol recall after 15 years and 23 years of follow-up in the Johns Hopkins Precursors Study. J Stud Alcohol Drugs 71:143-9
Parekh, Rulan S; Plantinga, Laura C; Kao, W H Linda et al. (2008) The association of sudden cardiac death with inflammation and other traditional risk factors. Kidney Int 74:1335-42
Wittink, Marsha N; Morales, Knashawn H; Meoni, Lucy A et al. (2008) Stability of preferences for end-of-life treatment after 3 years of follow-up: the Johns Hopkins Precursors Study. Arch Intern Med 168:2125-30
Wang, Nae-Yuh; Young, J Hunter; Meoni, Lucy A et al. (2008) Blood pressure change and risk of hypertension associated with parental hypertension: the Johns Hopkins Precursors Study. Arch Intern Med 168:643-8
Parekh, Rulan S; Kao, W H Linda; Meoni, Lucy A et al. (2007) Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the Family Investigation of Nephropathy and Diabetes. Clin J Am Soc Nephrol 2:1156-62
Plantinga, Laura C; Fink, Nancy E; Levin, Nathan W et al. (2007) Early, intermediate, and long-term risk factors for mortality in incident dialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study. Am J Kidney Dis 49:831-40

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