Jeanette S. Brown, M.D. is Professor of Obstetrics Gynecology and of Epidemiology & Biostatistics at the University of California, San Francisco (UCSF). She is Co-Director of the newly established UCSF Women?s Health Clinical Research Center and Director of the UCSF Women?s Urologic Research Group. Dr. Brown also developed and now is Director of UCSF Women?s Health Research Center Fellowship in Clinical Research and Associate Director of the UCSF/ San Francisco VAMC (SFVAMC) Women?s Health Clinical Research Fellowship. Additionally, Dr. Brown is Director of the UCSF Women?s Continence Center. Formal training in clinical research methods and support from a 4-year Mentored Clinical Scientist Award provided the experience and skills to become an independent investigator and build a multidisciplinary research team in patient-oriented research. The proposed research is designed to determine among women with diabetes: prevalence and incidence of urinary incontinence by type (urge, stress, and mixed) and severity, both overall and by race; risk factors associated with incontinence, especially aspects of diabetes severity (duration, treatment, glycemic control, presence of microvascular complications including retinopathy, nephropathy and neuropathy) that are associated with greater risk or severity of urinary incontinence; and whether interventions including glycemic control or weight reduction prevent or reduce severity of urinary incontinence among women with diabetes. Questionnaires, laboratory, and outcome data from a triad of diabetes studies including women with impaired glucose tolerance, type 2 and type 1 diabetes and 2 population-based cohort studies that include women with and without diabetes will be analyzed. Dr. Brown has the enthusiastic support of her department UCSF investigators and other internationally recognized clinical researchers to pursue her research goals. She is a senior mentor to young clinical investigators and will develop a unique joint Urogynecology and Urology 3-year clinical research fellowship.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK059294-02
Application #
6669107
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Bishop, Terry Rogers
Project Start
2002-09-30
Project End
2006-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
2
Fiscal Year
2003
Total Cost
$132,322
Indirect Cost
Name
University of California San Francisco
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Feldman, Mitchell D; Steinauer, Jody E; Khalili, Mandana et al. (2012) A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills. Clin Transl Sci 5:362-7
Johnson, Mallory O; Subak, Leslee L; Brown, Jeanette S et al. (2010) An innovative program to train health sciences researchers to be effective clinical and translational research mentors. Acad Med 85:484-9
Doshi, Ashmi M; Van Den Eeden, Stephen K; Morrill, Michelle Y et al. (2010) Women with diabetes: understanding urinary incontinence and help seeking behavior. J Urol 184:1402-7
Schwarz, Eleanor Bimla; Brown, Jeanette S; Creasman, Jennifer M et al. (2010) Lactation and maternal risk of type 2 diabetes: a population-based study. Am J Med 123:863.e1-6
Phelan, Suzanne; Grodstein, Francine; Brown, Jeanette S (2009) Clinical research in diabetes and urinary incontinence: what we know and need to know. J Urol 182:S14-7
Brown, Jeanette S (2009) Diabetic cystopathy--what does it mean? J Urol 181:13-4
Sarma, Aruna V; Kanaya, Alka; Nyberg, Leroy M et al. (2009) Risk factors for urinary incontinence among women with type 1 diabetes: findings from the epidemiology of diabetes interventions and complications study. Urology 73:1203-9
Feldman, Mitchell D; Huang, Laurence; Guglielmo, B Joseph et al. (2009) Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program. Clin Transl Sci 2:216-21