Jeanette S. Brown, MD is Professor of Obstetrics Gynecology and Reproductive Sciences, Urology, &Epidemiology at the University of California, San Francisco (UCSF). She is director of the ORWH/NIDDK funded UCSF Specialized Center of Research on Lower Urinary Tract Function in Women, UCSF Women's Continence Center, and the UCSF Women's Health Research Center Fellowship in Clinical Research. Dr. Brown is also co-director of the UCSF Clinical &Translational Sciences Training (CTST) program with primary responsibility for junior faculty career development. The UCSF CTST includes the NIH K30 Research Award and the Roadmap K12 Multi-disciplinary Career Development Award providing the training systems that are necessary to enhance the number, quality, and across-disciplinary skills of clinical and translational scientists. The proposed research is designed to determine, among women with pre-diabetes and diabetes: prevalence and incidence of urinary incontinence by type and severity, both overall and by race;risk factors associated with incontinence, especially aspects of diabetes severity (duration, treatment, glycemic control, presence of microvascular complications including retinopathy, nephropathy and neuropathy) that are associated with greater risk or severity of urinary incontinence;and whether interventions including glycemic control or weight reduction prevent or reduce severity of urinary incontinence among women with diabetes. Questionnaire, laboratory, and outcome data from two studies that include women with impaired glucose tolerance (pre-diabetes) as well as type 2 diabetes, and from a population-based cohort study that includes women with and without type 2 diabetes will be analyzed. Her long-term research goal is to contribute meaningfully to the prevention and clinical management of incontinence in women with diabetes. Dr. Brown has the enthusiastic support of her department, the UCSF CTST program, UCSF investigators, as well as national and international clinical and basic investigators to pursue her research goals. She is a senior mentor to numerous junior clinical investigators and will develop a unique UCSF Comprehensive Mentoring Program to train the next generation of mentors for clinical and translational researchers and assure that all young researchers have mentors appropriate to their research interest. Dr. Brown's long-term goal is to disseminate the successful elements of the model mentoring program to other academic centers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DK059294-09
Application #
8141453
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
2001-04-01
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2013-08-31
Support Year
9
Fiscal Year
2011
Total Cost
$174,917
Indirect Cost
Name
University of California San Francisco
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Feldman, Mitchell D; Steinauer, Jody E; Khalili, Mandana et al. (2012) A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills. Clin Transl Sci 5:362-7
Schwarz, Eleanor Bimla; Brown, Jeanette S; Creasman, Jennifer M et al. (2010) Lactation and maternal risk of type 2 diabetes: a population-based study. Am J Med 123:863.e1-6
Johnson, Mallory O; Subak, Leslee L; Brown, Jeanette S et al. (2010) An innovative program to train health sciences researchers to be effective clinical and translational research mentors. Acad Med 85:484-9
Doshi, Ashmi M; Van Den Eeden, Stephen K; Morrill, Michelle Y et al. (2010) Women with diabetes: understanding urinary incontinence and help seeking behavior. J Urol 184:1402-7
Phelan, Suzanne; Grodstein, Francine; Brown, Jeanette S (2009) Clinical research in diabetes and urinary incontinence: what we know and need to know. J Urol 182:S14-7
Brown, Jeanette S (2009) Diabetic cystopathy--what does it mean? J Urol 181:13-4
Sarma, Aruna V; Kanaya, Alka; Nyberg, Leroy M et al. (2009) Risk factors for urinary incontinence among women with type 1 diabetes: findings from the epidemiology of diabetes interventions and complications study. Urology 73:1203-9
Feldman, Mitchell D; Huang, Laurence; Guglielmo, B Joseph et al. (2009) Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program. Clin Transl Sci 2:216-21