The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Clayton Wiley, is a clinical and experimental Neuropathologist with extensive experience in research of neurological disease and in mentorship of physician scientists. Dr. Wiley's research has focused on neurodegenerative diseases with particular emphasis on how the AIDS virus mediates neurological damage. He is an active investigator in 2 funded centers studying the neurodegenerative disorders of Alzheimer's Disease and Parkinson's Disease, a non-funded Center for AIDS Research and is currently a funded Principal Investigator of grants focused on HIV mediated damage of the brain. In the initial 5 years of this K24, Dr. Wiley transitioned his predominantly tissue based studies into a more clinical orientation examining the use of state of the art imaging technology to monitor immune cell interactions with the nervous system using human and non-human primates. The final 5 years of proposed K24 funding will be directed at completing these studies and broadening the approach to other neurodegenerative disorders (e.g. Alzheimer's Disease). ? ? Dr. Wiley is also an active mentor for physician scientists at all stages of training and has been a leading innovator in development of training programs. During the first 5 years of K24 support Dr. Wiley co-directed 2 T32 training programs, served on the executive committees of K30 and K12 programs and re-built and directed the Pittsburgh MSTP, taking a moribund program and creating a model training system for budding clinical investigators. Renewal of the K24 proposal will protect Dr. Wiley's time from classroom, clinical and administrative responsibilities allowing him to focus his efforts on developing his clinical research program. In addition to advancing his clinical and preclinical studies, Dr. Wiley will engage in a rigorous clinical scientist training didactic curriculum and participate in national and international workshops on imaging, modeling and statistical analyses. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24MH001717-06A1
Application #
6891532
Study Section
Special Emphasis Panel (ZRG1-AARR-D (04))
Program Officer
Joseph, Jeymohan
Project Start
1999-07-15
Project End
2010-03-31
Budget Start
2005-04-11
Budget End
2006-03-31
Support Year
6
Fiscal Year
2005
Total Cost
$133,406
Indirect Cost
Name
University of Pittsburgh
Department
Pathology
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Bissel, Stephanie J; Kofler, Julia; Nyaundi, Julia et al. (2016) Cerebrospinal Fluid Biomarkers of Simian Immunodeficiency Virus Encephalitis : CSF Biomarkers of SIV Encephalitis. J Neuroimmune Pharmacol 11:332-47
Giles, Brendan M; Bissel, Stephanie J; Dealmeida, Dilhari R et al. (2012) Antibody breadth and protective efficacy are increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin-based H5N1 virus-like particle vaccines. Clin Vaccine Immunol 19:128-39
Bonneh-Barkay, Dafna; Bissel, Stephanie J; Kofler, Julia et al. (2012) Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation. Brain Pathol 22:530-46
Kofler, Julia; Lopresti, Brian; Janssen, Chris et al. (2012) Preventive immunization of aged and juvenile non-human primates to beta-amyloid. J Neuroinflammation 9:84
Giles, Brendan M; Crevar, Corey J; Carter, Donald M et al. (2012) A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection. J Infect Dis 205:1562-70
Bonneh-Barkay, Dafna; Wang, Guoji; Starkey, Adam et al. (2010) In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation 7:34
Bonneh-Barkay, Dafna; Zagadailov, Pavel; Zou, Huichao et al. (2010) YKL-40 expression in traumatic brain injury: an initial analysis. J Neurotrauma 27:1215-23
Horbinski, Craig; Wang, Guoji; Wiley, Clayton A (2010) YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. Int J Clin Exp Pathol 3:226-37
Bonneh-Barkay, Dafna; Wiley, Clayton A (2009) Brain extracellular matrix in neurodegeneration. Brain Pathol 19:573-85
Venneti, Sriram; Lopresti, Brian J; Wang, Guoji et al. (2009) PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET. Neurobiol Aging 30:1217-26

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