The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Clayton Wiley, is a clinical and experimental Neuropathologist with extensive experience in research of neurological disease and in mentorship of physician scientists. Dr. Wiley's research has focused on neurodegenerative diseases with particular emphasis on how the AIDS virus mediates neurological damage. He is an active investigator in 2 funded centers studying the neurodegenerative disorders of Alzheimer's Disease and Parkinson's Disease, a non-funded Center for AIDS Research and is currently a funded Principal Investigator of grants focused on HIV mediated damage of the brain. In the initial 5 years of this K24, Dr. Wiley transitioned his predominantly tissue based studies into a more clinical orientation examining the use of state of the art imaging technology to monitor immune cell interactions with the nervous system using human and non-human primates. The final 5 years of proposed K24 funding will be directed at completing these studies and broadening the approach to other neurodegenerative disorders (e.g. Alzheimer's Disease). ? ? Dr. Wiley is also an active mentor for physician scientists at all stages of training and has been a leading innovator in development of training programs. During the first 5 years of K24 support Dr. Wiley co-directed 2 T32 training programs, served on the executive committees of K30 and K12 programs and re-built and directed the Pittsburgh MSTP, taking a moribund program and creating a model training system for budding clinical investigators. Renewal of the K24 proposal will protect Dr. Wiley's time from classroom, clinical and administrative responsibilities allowing him to focus his efforts on developing his clinical research program. In addition to advancing his clinical and preclinical studies, Dr. Wiley will engage in a rigorous clinical scientist training didactic curriculum and participate in national and international workshops on imaging, modeling and statistical analyses. ? ? ?

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Special Emphasis Panel (ZRG1-AARR-D (04))
Program Officer
Joseph, Jeymohan
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University of Pittsburgh
Schools of Medicine
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Bissel, Stephanie J; Kofler, Julia; Nyaundi, Julia et al. (2016) Cerebrospinal Fluid Biomarkers of Simian Immunodeficiency Virus Encephalitis : CSF Biomarkers of SIV Encephalitis. J Neuroimmune Pharmacol 11:332-47
Kofler, Julia; Lopresti, Brian; Janssen, Chris et al. (2012) Preventive immunization of aged and juvenile non-human primates to beta-amyloid. J Neuroinflammation 9:84
Giles, Brendan M; Crevar, Corey J; Carter, Donald M et al. (2012) A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection. J Infect Dis 205:1562-70
Giles, Brendan M; Bissel, Stephanie J; Dealmeida, Dilhari R et al. (2012) Antibody breadth and protective efficacy are increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin-based H5N1 virus-like particle vaccines. Clin Vaccine Immunol 19:128-39
Bonneh-Barkay, Dafna; Bissel, Stephanie J; Kofler, Julia et al. (2012) Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation. Brain Pathol 22:530-46
Bonneh-Barkay, Dafna; Wang, Guoji; Starkey, Adam et al. (2010) In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation 7:34
Bonneh-Barkay, Dafna; Zagadailov, Pavel; Zou, Huichao et al. (2010) YKL-40 expression in traumatic brain injury: an initial analysis. J Neurotrauma 27:1215-23
Horbinski, Craig; Wang, Guoji; Wiley, Clayton A (2010) YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas. Int J Clin Exp Pathol 3:226-37
Kellermier, Harry; Wang, Guoji; Wiley, Clayton (2009) Iron localization in superficial siderosis of the central nervous system. Neuropathology 29:187-95
Wiley, Clayton A; Lopresti, Brian J; Venneti, Sriram et al. (2009) Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 66:60-7

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