The applicant proposes to acquire training in functional neuroimaging technology, including fMRI and PET. This will expand her expertise in neuroimaging and psychiatry from the structural realm into the functional neuroanatomic domain, and further her research endeavors in attempting to understand the neuroanatomic underpinnings of psychiatric disorders. The applicant proposes to work extensively with the Brain Mapping Division at UCLA and proposes an fMRI research project to explore brain changes that occur with mood changes in mania and depression. She will look for blood flow changes that occur in the amygdala and frontal lobe as a function of changing mood state. Specifically, she will assess fMRI signal activation in the amygdala and frontal cortex (anterior cingulate, orbitofrontal and lateral prefrontal areas) in bipolar subjects as they go from either mania to euthymia or depression to euthymia.
| Brooks 3rd, J O; Vizueta, N; Penfold, C et al. (2015) Prefrontal hypoactivation during working memory in bipolar II depression. Psychol Med 45:1731-40 |
| Townsend, Jennifer D; Sugar, Catherine A; Walshaw, Patricia D et al. (2013) Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity. J Affect Disord 147:389-96 |
| Foland-Ross, Lara C; Thompson, Paul M; Sugar, Catherine A et al. (2013) Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium. Psychiatry Res 211:195-201 |
| Townsend, Jennifer D; Torrisi, Salvatore J; Lieberman, Matthew D et al. (2013) Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry 73:127-35 |
| Barysheva, Marina; Jahanshad, Neda; Foland-Ross, Lara et al. (2013) White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study. Neuroimage Clin 2:558-68 |
| Torrisi, Salvatore; Moody, Teena D; Vizueta, Nathalie et al. (2013) Differences in resting corticolimbic functional connectivity in bipolar I euthymia. Bipolar Disord 15:156-66 |
| Strakowski, Stephen M; Adler, Caleb M; Almeida, Jorge et al. (2012) The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord 14:313-25 |
| Foland-Ross, Lara C; Brooks 3rd, John O; Mintz, Jim et al. (2012) Mood-state effects on amygdala volume in bipolar disorder. J Affect Disord 139:298-301 |
| Vizueta, Nathalie; Rudie, Jeffrey D; Townsend, Jennifer D et al. (2012) Regional fMRI hypoactivation and altered functional connectivity during emotion processing in nonmedicated depressed patients with bipolar II disorder. Am J Psychiatry 169:831-40 |
| Hegarty, Catherine E; Foland-Ross, Lara C; Narr, Katherine L et al. (2012) Anterior cingulate activation relates to local cortical thickness. Neuroreport 23:420-4 |
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