This K24 Midcareer Investigator Award in Patient-Oriented Research is a competitive renewal that will provide five years of support to enhance a program of research and mentoring for the applicant in Neuroimaging in Depression Treatment Studies. Major depression in late life is an important health problem with a large and growing number of affected individuals. A progress report describes important mentoring and research activities to date. During the current K24 award period we have provided mentoring through involvement of mentees in ongoing NIH grants, through consultation to faculty members on neuroimaging techniques and through R25, K12 and K30 initiatives. Findings in ongoing studies include: 1) Late life depression (LLD) subjects have significantly greater white matter hyperintensities interrupting specific regional pathways involved in mood regulation;2) In addition, using fMRI and PET, we have identified disruptions in emotional circuitry and 3) regional loss of 5-HT2A receptors. The applicant has completed career development activities described in the previous application in diffusion tensor imaging, resulting in a new NIMH initiative and a NARSAD Independent Investigator Award. The overall goals of the applicant's research remain the same: 1) To engage in teaching and training activities that will help produce the next generation of clinical researchers in the area of geriatric psychiatry neuroimaging research;2) To obtain career development training that will enhance an ongoing program of research;and 3) To continue to conduct an ongoing program of research studies focused on neuroimaging in depression treatment studies. The proposal describes the applicant's current research program and the career development and mentoring activities planned for the 5-year renewal of the K24. Three NIH grants are ongoing: one will determine if severity of WMH and frontal executive dysfunction predict less antidepressant treatment response;another measures dysregulation of emotional circuitry in depression and a third investigates amyloid abnormalities in LLD. A NARSAD grant will determine if LLD subjects have decreased white matter connectivity in important pathways involved in emotional regulation. Career development activities are described for the PI to learn functional connectivity mapping and to apply these measures in ongoing research studies. Trainees will engage in these projects, take coursework in neuroimaging and clinical investigation and complete a research proposal over the 2-year training period. K24 support will provide the applicant with protected time to continue to carry out depression studies in late life depression and to increase the mentoring of beginning clinical investigators in neuroimaging studies in depression.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH079510-09
Application #
8118586
Study Section
Interventions Committee for Disorders Related to Schizophrenia, Late Life, or Personality (ITSP)
Program Officer
Evans, Jovier D
Project Start
2002-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2011
Total Cost
$169,885
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Yang, Zhen; Oathes, Desmond J; Linn, Kristin A et al. (2018) Cognitive Behavioral Therapy Is Associated With Enhanced Cognitive Control Network Activity in Major Depression and Posttraumatic Stress Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 3:311-319
Shou, Haochang; Yang, Zhen; Satterthwaite, Theodore D et al. (2017) Cognitive behavioral therapy increases amygdala connectivity with the cognitive control network in both MDD and PTSD. Neuroimage Clin 14:464-470
Satterthwaite, T D; Cook, P A; Bruce, S E et al. (2016) Dimensional depression severity in women with major depression and post-traumatic stress disorder correlates with fronto-amygdalar hypoconnectivty. Mol Psychiatry 21:894-902
Hsu, Phillip J; Shou, Haochang; Benzinger, Tammie et al. (2015) Amyloid burden in cognitively normal elderly is associated with preferential hippocampal subfield volume loss. J Alzheimers Dis 45:27-33
McConathy, Jonathan; Sheline, Yvette I (2015) Imaging biomarkers associated with cognitive decline: a review. Biol Psychiatry 77:685-92
Conway, Charles R; Chibnall, John T; Cumming, Paul et al. (2014) Antidepressant response to aripiprazole augmentation associated with enhanced FDOPA utilization in striatum: a preliminary PET study. Psychiatry Res 221:231-9
Disabato, Brianne M; Morris, Carrie; Hranilovich, Jennifer et al. (2014) Comparison of brain structural variables, neuropsychological factors, and treatment outcome in early-onset versus late-onset late-life depression. Am J Geriatr Psychiatry 22:1039-46
Sheline, Yvette I; West, Tim; Yarasheski, Kevin et al. (2014) An antidepressant decreases CSF A? production in healthy individuals and in transgenic AD mice. Sci Transl Med 6:236re4
Sheline, Yvette I; Raichle, Marcus E (2013) Resting state functional connectivity in preclinical Alzheimer's disease. Biol Psychiatry 74:340-7
Conway, Charles R; Chibnall, John T; Gebara, Marie Anne et al. (2013) Association of cerebral metabolic activity changes with vagus nerve stimulation antidepressant response in treatment-resistant depression. Brain Stimul 6:788-97

Showing the most recent 10 out of 22 publications