The 1990s were heralded as the decade of the mouse. As the new century approaches, the mouse appears to be an even greater biomedical tool. A limiting factor is not the means to generate new mutations or find spontaneous ones, rather it is the expertise needed to critically evaluate these animals and interpret their lesions with comparison to human diseases. This midcareer award takes advantage of the unique resources of mice and focused scientists at The Jackson laboratory and particularly the experience and expertise of Dr. John Sundberg, the staff pathologist for over 12 years, to train the new generation of comparative pathologists and biomedical researchers in this area. A variety of perfected personalized training methods for long and short term visits by investigators will be used to teach basic mouse pathobiology and methodology. A small research project focused on the pathobiology of the spontaneous lanceolate hair mouse mutation will include high resolution mapping of the mutant gene locus with candidate gene screening in both mutant mice and humans with an homologous disease to be used as a training aid.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Midcareer Investigator Award in Biomedical and Behavioral Research (K26)
Project #
5K26RR000173-02
Application #
6394560
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Grieder, Franziska B
Project Start
2000-06-01
Project End
2005-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
2
Fiscal Year
2001
Total Cost
$98,494
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Sundberg, John P; Boyd, Kelli; Hogenesch, Harm et al. (2017) Training mouse pathologists: 15 years of workshops on the pathology of mouse models of human disease. Lab Anim (NY) 46:204-206
Wu, Baojin; Herbert Pratt, C; Potter, Christopher S et al. (2013) R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla. Exp Dermatol 22:234-6
Taylor, D K; Bubier, J A; Silva, K A et al. (2012) Development, structure, and keratin expression in C57BL/6J mouse eccrine glands. Vet Pathol 49:146-54
Sundberg, J P; Taylor, D; Lorch, G et al. (2011) Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans. Vet Pathol 48:513-24
Liu, Y; Sundberg, J P; Das, S et al. (2010) Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr). Vet Pathol 47:167-76
Giehl, K A; Potter, C S; Wu, B et al. (2009) Hair interior defect in AKR/J mice. Clin Exp Dermatol 34:509-17
Ghim, Shinje; Jenson, A Bennett; Bubier, Jason A et al. (2008) Cataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14. Exp Mol Pathol 85:77-82
Bleich, Andre; Kirsch, Petra; Sahly, Hany et al. (2008) Klebsiella oxytoca: opportunistic infections in laboratory rodents. Lab Anim 42:369-75
Bleich, Andre; Sundberg, John P; Smoczek, Anna et al. (2008) Sensitivity to Escherichia coli Nissle 1917 in mice is dependent on environment and genetic background. Int J Exp Pathol 89:45-54
Chen, Jiang; Jaeger, Karin; Den, Zhining et al. (2008) Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita. J Invest Dermatol 128:270-9

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