The goal of the South Carolina Clinical and Translational Research Institute (SCTR) is to create a sustainable home at the Medical University of South Carolina (MUSC) to advance clinical and translational research as a distinct discipline and facilitate collaboration across multiple disciplines. The overall approach focuses on: (1) implementing important advances in biomedical science to create opportunities for discovery, (2) removing barriers to facilitate the linkage of knowledge, experience and expertise across disciplinary boundaries, (3) providing training and mentoring experiences to enhance the pipeline for clinical and translational researchers with diverse training and backgrounds, and (4) fostering community engagement with a rapidly growing statewide population that is underserved by many systems to improve their participation and health outcomes. MUSC has long-standing experience leading successful clinical and translational research efforts that span the state. It is the leading state institution in extramurally funded research activities and has a rich research training portfolio. SCTR was established in 2007 with the vision that it would be the """"""""agent of change"""""""" in transforming the research culture at MUSC and statewide via strong relationships with academic and community-based affiliates. Great progress has already been made including the development of an institutional K12 Career Development Program in Clinical and Translational Research, implementation of a pilot project program that funded 29 projects in the first two competitive rounds, and establishment of a robust collaboration with the NIH-funded CTSA at Vanderbilt University for assistance in the SCTR Biomedical Informatics Program. Joining the national CTSA Consortium will accelerate progress by further facilitating (1) development and interoperability of biomedical informatics systems, (2) active exchange of best processes and best practices in evidence-based medicine and community engagement, (3) advancement of clinical and translational science as a discipline and career path;and (4) shared knowledge, experience and collective influence in setting regional and national research agendas and health policy designed to generate the transformative results envisioned by the NIH Roadmap.

Public Health Relevance

SCTR will bring together scientists, clinicians and the lay community to address diseases that commonly impact the citizens of South Carolina. SCTR will coordinate resources and expertise statewide in efficient, innovative approaches to research. Through SCTR, a new generation of researchers will be trained to work across multiple disciplines in collaboration with community members so that scientific discovery is relevant anri ranifllv fran.slaffid tn frnnt-linFt treafnnRnt .qeffinn.s for maximum imnant nn hftalth niifrnmes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Mentored Career Development Award (KL2)
Project #
1KL2RR029880-01
Application #
7878910
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Program Officer
Purucker, Mary E
Project Start
2009-07-14
Project End
2014-03-31
Budget Start
2009-07-14
Budget End
2010-03-31
Support Year
1
Fiscal Year
2009
Total Cost
$438,382
Indirect Cost
Name
Medical University of South Carolina
Department
Psychiatry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Hughes Jr, Michael G; Tucker, William W; Reddy, Sreelatha et al. (2017) Rate of hepatitis C viral clearance by human livers in human patients: Liver transplantation modeling primary infection and implications for studying entry inhibition. PLoS One 12:e0180719
Chhabra, Saurabh; Jain, Sandeep; Wallace, Caroline et al. (2015) High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma. J Hematol Oncol 8:77
Bonilha, Heather Shaw; Focht, Kendrea L; Martin-Harris, Bonnie (2015) Rater methodology for stroboscopy: a systematic review. J Voice 29:101-8
Hartwell, Emily E; Pfeifer, James G; McCauley, Jenna L et al. (2014) Sleep disturbances and pain among individuals with prescription opioid dependence. Addict Behav 39:1537-42
McCauley, Jenna L; Mercer, Mary Ashley; Barth, Kelly S et al. (2014) Pain management perceptions among prescription opioid dependent individuals. Drug Alcohol Depend 142:354-8
Manevich, Y; Hutchens, S; Halushka, P V et al. (2014) Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome. Free Radic Biol Med 72:210-21
Cunningham, Melissa A; Wirth, Jena R; Freeman, Linnea R et al. (2014) Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus. J Neuroinflammation 11:171
Bonilha, Heather Shaw; Simpson, Annie N; Ellis, Charles et al. (2014) The one-year attributable cost of post-stroke dysphagia. Dysphagia 29:545-52
Bonilha, Heather Shaw; Blair, Julie; Carnes, Brittni et al. (2013) Preliminary investigation of the effect of pulse rate on judgments of swallowing impairment and treatment recommendations. Dysphagia 28:528-38
Bonilha, Heather Shaw; Humphries, Kate; Blair, Julie et al. (2013) Radiation exposure time during MBSS: influence of swallowing impairment severity, medical diagnosis, clinician experience, and standardized protocol use. Dysphagia 28:77-85

Showing the most recent 10 out of 33 publications