This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hereditary nature of cancer has been noted for many years. Between five to ten percent of cancers are due to hereditary cancer syndromes. Developments have been made in the identification of genetic alterations associated with specific hereditary cancer syndromes. However, for many cancers optimal screening and preventive measures have not yet been determined, and the hereditary components of many cancers remain unidentified. This research project is studying the genetic basis of cancer. The goals of this research are to identify genetic alterations associated with cancer risk and development, and to use this information to improve the identification, screening, and management of individuals and families at-risk for cancer. Participants will be asked to provide information about their personal and family medical history information and to give samples of blood and tumor tissue to be used for cancer genetics research. Participants will be contacted periodically to update their medical and family history information, and they will be asked to share information about the registry with family members. Individual results from this research cannot be reported, but participants can be notified of overall study findings. There is no planned end date for this study. The researchers plan to continue to identify and follow families for as long as possible. However, participants can chose to withdraw at any time.
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