The purpose of this study is: 1) to determine the maximally tolerated dose (MTD) of lometrexol when given every three weeks to patients receiving 5 mg of folic acid IV, 1 hr preceding lometrexol and to describe the toxicities at each dose schedule studied and 2) to evaluate the pharmacokinetics of lometrexol in patients receiving exogenous folates, and compre them with pharmacokinetics in preceding trials.

Project Start
Project End
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
39
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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