This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator.
SPECIFIC AIMS : 1. Collect initial data on the cardiovascular, subjective, and reinforcing effects of methamphetamine during treatment with modafinil methamphetamine-dependent subjects. Based on results of prior trials that assessed the safety and efficacy of modafinil for cocaine dependence [Dackis, 2003 #3188;Dackis, 2005 #3869], we anticipate no adverse interaction (such as an enhancement of the cardiovascular effects of methamphetamine), and predict that modafinil will reduce the subjective and reinforcing effects of methamphetamine. 2. Determine whether modafinil (both in the absence and presence of methamphetamine) improves cognitive functioning, especially related to inhibitory control. Chronic abuse is associated with poor response inhibition and other neurocognitive deficits related to executive function (e.g., Kalechstein 2003a). Prior reports suggest that modafinil improves similar cognitive deficits in other clinical populations (e.g., Turner 2004a). Participants will undergo behavioral tests throughout the trial to monitor both acute effects of the drug on cognitive measures of inhibitory control, as well as effects during brief chronic dosing. We anticipate that modafinil administration will be associated with improved performance on tests of inhibitory control.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000865-36
Application #
7951561
Study Section
Special Emphasis Panel (ZRR1-CR-4 (01))
Project Start
2009-04-01
Project End
2009-11-30
Budget Start
2009-04-01
Budget End
2009-11-30
Support Year
36
Fiscal Year
2009
Total Cost
$68,961
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Ellsworth, G B; Lensing, S Y; Ogilvie, C B et al. (2018) A delayed dose of quadrivalent human papillomavirus vaccine demonstrates immune memory in HIV-1-infected men. Papillomavirus Res 6:11-14
Goldman, Noreen; Glei, Dana A; Weinstein, Maxine (2018) Declining mental health among disadvantaged Americans. Proc Natl Acad Sci U S A 115:7290-7295
Dean, Andy C; Morales, Angelica M; Hellemann, Gerhard et al. (2018) Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness. Neuropsychopharmacology 43:1745-1752
Nersesian, Paula V; Han, Hae-Ra; Yenokyan, Gayane et al. (2018) Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States. Soc Sci Med 209:174-181
Glei, Dana A; Goldman, Noreen; Ryff, Carol D et al. (2018) Physical Function in U.S. Older Adults Compared With Other Populations: A Multinational Study. J Aging Health :898264318759378
Stephan, Yannick; Sutin, Angelina R; Bayard, Sophie et al. (2018) Personality and sleep quality: Evidence from four prospective studies. Health Psychol 37:271-281
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Burggren, Alison C; Mahmood, Zanjbeel; Harrison, Theresa M et al. (2017) Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ?4 variant. Alzheimers Dement 13:739-748
Sloan, Richard P; Schwarz, Emilie; McKinley, Paula S et al. (2017) Vagally-mediated heart rate variability and indices of well-being: Results of a nationally representative study. Health Psychol 36:73-81
Chung, Joon (2017) Social support, social strain, sleep quality, and actigraphic sleep characteristics: evidence from a national survey of US adults. Sleep Health 3:22-27

Showing the most recent 10 out of 1085 publications