The Baltimore Longitudinal Study of Aging (BLSA) is an ongoing, multidisciplinary research project aimed at understanding the aging process in men and women. Longitudinal changes are assessed by having a cohort of community-dwelling subjects of both sexes, and ages across the adult lifespan, who return every two years for a comprehensive evaluation. Major goals of the study are to better understand age-related changes in various organ systems and their interrelationships, to characterize the transition from normal to pathological aging, and to relate functional changes in these systems to the development of specific diseases and mortality. The purposes of the BLSA are fourfold: 1) to obtain repeated measures of physiological, pathological, biochemical, and psychological variables on longitudinal study participants; 2) to compare levels of function repeatedly measured in age and sex cohorts; 3) to follow changes in individual participants and groups of participants up to and beyond age-related endpoints and disease events; and 4) to identify characteristics of individual participants that may be markers of biological aging, and to analyze their influence on clinical outcomes. Cross-sectional characterization of multiple parameters is also obtained and differences related to age, sex and race are quantified. Aging, secular, and period effects are examined. Relationships between such variables as nutritional habits, customary levels of physical activity, and adaptations to age-associated physical disability with glucose metabolism, cardiovascular function and specific disease outcome are being examined. Studies of some BLSA participants are conducted on Johns Hopkins Bayview Medical Center's GCRC and include assessments of nutritional patterns and oral glucose tolerance testing. Over the past year, major reports have been published in relation to diabetes and glucose metabolism, osteoarthritis, Alzheimer's Disease, cardiovascular disease, prostate cancer, and women's health. The BLSA is part of the Intramural Research Program of the National Institute of Aging and wholy supported by the NIA. The GCRC staff intereviewed 379 of the BLSA participants for nutritional assessment. Twenth-five of approximately 500 subjects seen during the reporting period were admitted to the GCRC for testing. The enrollment period for this study is ongoing.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Unick, Jessica L; Gaussoin, Sarah A; Hill, James O et al. (2017) Objectively Assessed Physical Activity and Weight Loss Maintenance among Individuals Enrolled in a Lifestyle Intervention. Obesity (Silver Spring) 25:1903-1909
Li, Tianjing; Wieland, L Susan; Oh, Esther et al. (2017) Design considerations of a randomized controlled trial of sedation level during hip fracture repair surgery: a strategy to reduce the incidence of postoperative delirium in elderly patients. Clin Trials 14:299-307
Sammut, Amanda; Shea, Steven; Blumenthal, Roger S et al. (2017) Albuminuria in Rheumatoid Arthritis: Associations With Rheumatoid Arthritis Characteristics and Subclinical Atherosclerosis. Arthritis Care Res (Hoboken) 69:1799-1808
Baker, Joshua F; Giles, Jon T; Weber, David et al. (2017) Assessment of muscle mass relative to fat mass and associations with physical functioning in rheumatoid arthritis. Rheumatology (Oxford) 56:981-988
Johnson, Karen C; Bray, George A; Cheskin, Lawrence J et al. (2017) The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial. J Bone Miner Res 32:2278-2287
Chao, Ariana M; Wadden, Thomas A; Gorin, Amy A et al. (2017) Binge Eating and Weight Loss Outcomes in Individuals with Type 2 Diabetes: 4-Year Results from the Look AHEAD Study. Obesity (Silver Spring) 25:1830-1837
Park, H-W; Tse, S; Yang, W et al. (2017) A genetic factor associated with low final bone mineral density in children after a long-term glucocorticoids treatment. Pharmacogenomics J 17:180-185
McGeachie, Michael J; Yates, Katherine P; Zhou, Xiaobo et al. (2016) Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med 194:1465-1474
Marquez, Becky; Anderson, Andrea; Wing, Rena R et al. (2016) The relationship of social support with treatment adherence and weight loss in Latinos with type 2 diabetes. Obesity (Silver Spring) 24:568-75
Kavouspour, Chitra; Wang, NaeYuh; Mears, Simon C et al. (2016) Surgical procedure and postoperative delirium in geriatric hip fracture patients. Eur J Anaesthesiol 33:230-1

Showing the most recent 10 out of 406 publications