Project Start
Project End
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Budget End
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Novartis Vaccines and Diagnostics, Inc.
United States
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Spearman, Paul; Lally, Michelle A; Elizaga, Marnie et al. (2011) A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers. J Infect Dis 203:1165-73
Lewis, David J M; Huo, Zhiming; Barnett, Susan et al. (2009) Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One 4:e6999
Goodsell, Amanda; Zhou, Fengmin; Gupta, Soumi et al. (2008) Beta7-integrin-independent enhancement of mucosal and systemic anti-HIV antibody responses following combined mucosal and systemic gene delivery. Immunology 123:378-89
Caputo, Antonella; Brocca-Cofano, Egidio; Castaldello, Arianna et al. (2008) Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin. Vaccine 26:1214-27
Brave, Andreas; Hinkula, Jorma; Cafaro, Aurelio et al. (2007) Candidate HIV-1 gp140DeltaV2, Gag and Tat vaccines protect against experimental HIV-1/MuLV challenge. Vaccine 25:6882-90
Megede, Jan Zur; Otten, Gillis R; Doe, Barbara et al. (2006) Evaluation of human immunodeficiency virus type 1 subtype C gag, pol, and gagpol DNA and alphavirus replicon vaccines. Vaccine 24:2755-63
Otten, Gillis R; Schaefer, Mary; Doe, Barbara et al. (2006) Potent immunogenicity of an HIV-1 gag-pol fusion DNA vaccine delivered by in vivo electroporation. Vaccine 24:4503-9
Vajdy, Michael; Singh, Manmohan (2006) Intranasal delivery of vaccines against HIV. Expert Opin Drug Deliv 3:247-59
Lian, Ying; Srivastava, Indresh; Gomez-Roman, V Raul et al. (2005) Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain. J Virol 79:13338-49
Barackman, John; Prado, Isaias; Karunatilake, Chulani et al. (2004) Evaluation of on-line high-performance size-exclusion chromatography, differential refractometry, and multi-angle laser light scattering analysis for the monitoring of the oligomeric state of human immunodeficiency virus vaccine protein antigen. J Chromatogr A 1043:57-64

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