Abstract

This contract is one part of the pre-clinical portion of the NIAID Antiviral Substances Program. The Program supports five separate awards to investigators who have developed animal models of viral infections which can be used to test the activity of antiviral agents in vivo. Compounds are evaluated for efficacy both therapeutically and prophylactically. Studies of drug toxicity and effects of drug treatment on the immune response to infection are also pursued. Combination chemotherapy studies are encouraged. The currently awarded series of contractors have at their disposal the following models: University of Utah - herpes encephalitis in mouse, neonatal herpes in mouse, genital herpes in the guinea pig; University of Massachusetts - influenza in the mouse; Yale University - cytomegalovirus in the guinea pig; Baylor College of Medicine - respiratory syncytial virus in the cotton rat, and Tulane University - simian varicella and parainfluenza type 3 in the African Green monkey.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI062518-007
Application #
3595171
Study Section
Project Start
1985-11-24
Project End
1990-11-13
Budget Start
1988-10-24
Budget End
1989-11-13
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Meade, E A; Wotring, L L; Drach, J C et al. (1992) Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues. J Med Chem 35:526-33
Chatterjee, S; Burns, P; Whitley, R J et al. (1992) Effect of (S)-1-[(3-hydroxy-2-phosphonyl methoxy) propyl] cytosine on the replication and morphogenesis of herpes simplex virus type 1. Antiviral Res 19:181-92
Simecka, J W; Patel, P; Kern, E R (1992) Immunotoxic potential of antiviral drugs: effects of ganciclovir and (S)-1-(3-hydroxy-2-phosphonylmethoxy propyl) cytosine on lymphocyte transformation and delayed-type hypersensitivity responses. Antiviral Res 18:53-64
Lee, P H; Su, M H; Kern, E R et al. (1992) Novel animal model for evaluating topical efficacy of antiviral agents: flux versus efficacy correlations in the acyclovir treatment of cutaneous herpes simplex virus type 1 (HSV-1) infections in hairless mice. Pharm Res 9:979-89
Townsend, L B; Drach, J C; Wotring, L L et al. (1991) Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents. Farmaco 46:113-39
Kern, E R (1991) Value of animal models to evaluate agents with potential activity against human cytomegalovirus. Transplant Proc 23:152-5, discussion 155
Pudlo, J S; Nassiri, M R; Kern, E R et al. (1990) Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines. J Med Chem 33:1984-92
Krawczyk, S H; Bernier-Rodriguez, M; Nassiri, M R et al. (1990) Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections. J Med Chem 33:3160-9