Project Start
1985-11-24
Project End
1990-11-13
Budget Start
1989-06-14
Budget End
1989-11-13
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Simecka, J W; Patel, P; Kern, E R (1992) Immunotoxic potential of antiviral drugs: effects of ganciclovir and (S)-1-(3-hydroxy-2-phosphonylmethoxy propyl) cytosine on lymphocyte transformation and delayed-type hypersensitivity responses. Antiviral Res 18:53-64
Lee, P H; Su, M H; Kern, E R et al. (1992) Novel animal model for evaluating topical efficacy of antiviral agents: flux versus efficacy correlations in the acyclovir treatment of cutaneous herpes simplex virus type 1 (HSV-1) infections in hairless mice. Pharm Res 9:979-89
Meade, E A; Wotring, L L; Drach, J C et al. (1992) Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues. J Med Chem 35:526-33
Chatterjee, S; Burns, P; Whitley, R J et al. (1992) Effect of (S)-1-[(3-hydroxy-2-phosphonyl methoxy) propyl] cytosine on the replication and morphogenesis of herpes simplex virus type 1. Antiviral Res 19:181-92
Townsend, L B; Drach, J C; Wotring, L L et al. (1991) Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents. Farmaco 46:113-39
Kern, E R (1991) Value of animal models to evaluate agents with potential activity against human cytomegalovirus. Transplant Proc 23:152-5, discussion 155
Pudlo, J S; Nassiri, M R; Kern, E R et al. (1990) Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines. J Med Chem 33:1984-92
Krawczyk, S H; Bernier-Rodriguez, M; Nassiri, M R et al. (1990) Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections. J Med Chem 33:3160-9