The primary objective of this project is to cyclically maintain 3 filarial parasites by alternate passage through vertebrate and invertebrate hosts and supply limited amounts of these research materials to investigators. These filarial systems are as follows: (1) Brugia pahangi in jirds, dogs, cats, and Aedes aegypti (Liverpool strain) mosquitoes; (2) B. malayi in jirds, cats and A.aegypti; and (3) Dirofilaria immitis in dogs and A. aegypti.

Project Start
1996-03-15
Project End
2003-03-14
Budget Start
1999-03-25
Budget End
2000-03-14
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Georgia
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Higazi, Tarig B; Deoliveira, Ana; Katholi, Charles R et al. (2005) Identification of elements essential for transcription in Brugia malayi promoters. J Mol Biol 353:1-13
Shu, Limin; Katholi, Charles R; Higazi, Tarig et al. (2003) Analysis of the Brugia malayi HSP70 promoter using a homologous transient transfection system. Mol Biochem Parasitol 128:67-75
Merriweather, A; Guenzler, V; Brenner, M et al. (2001) Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase. Mol Biochem Parasitol 116:185-97