Abstract

The primary objective of this project is to cyclically maintain 3 filarial parasites by alternate passage through vertebrate and invertebrate hosts and supply limited amounts of these research materials to investigators. These filarial systems are as follows: (1) Brugia pahangi in jirds, dogs, cats, and Aedes aegypti (Liverpool strain) mosquitoes; (2) B. malayi in jirds, cats and A.aegypti; and (3) Dirofilaria immitis in dogs and A. aegypti.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI065283-004
Application #
6337257
Study Section
Project Start
1996-03-15
Project End
2003-03-14
Budget Start
2000-06-07
Budget End
2001-03-14
Support Year
Fiscal Year
2000
Total Cost
$244,187
Indirect Cost

  Institution

Name
University of Georgia
Department
Microbiology/Immun/Virology
Type
Schools of Veterinary Medicine
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602

  Publications

Higazi, Tarig B; Deoliveira, Ana; Katholi, Charles R et al. (2005) Identification of elements essential for transcription in Brugia malayi promoters. J Mol Biol 353:1-13
Shu, Limin; Katholi, Charles R; Higazi, Tarig et al. (2003) Analysis of the Brugia malayi HSP70 promoter using a homologous transient transfection system. Mol Biochem Parasitol 128:67-75
Merriweather, A; Guenzler, V; Brenner, M et al. (2001) Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase. Mol Biochem Parasitol 116:185-97