Abstract

The Division of Molecular Virology and Immunology, Georgetown University, supports the NIAID intramural and contract-sponsored extramural programs requiring the expertise and equipment of the NIAID special support laboratory at 5640 Fishers Lane, Rockville, Maryland. Additional work will be conducted outside the Rockville facility to support the NIAID intramural studies of the virology of the causative agent of AIDS (i.e., the isolation of virus from clinical specimens, purification and characterization of antigens, modification and development of assays for virus and antibodies to the virus). In addition to AIDS virus, the research efforts center on hepadna viruses, hepatitis delta virus; a hepatitis testing laboratory is provided; an electron microscope facility for collaborative studies on membrane receptors in neutrophil activation leading to chemotaxis and/or degranulation; and, mast cell aberrations in a variety of conditions associated with physiologic or pathologic mastocytosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI072623-000
Application #
2296691
Study Section
Project Start
1986-10-16
Project End
1993-10-15
Budget Start
1986-10-16
Budget End
1987-10-15
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Microbiology/Immun/Virology
Type
School of Medicine & Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Korba, B E; Cote, P; Hornbuckle, W et al. (2000) Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans. Hepatology 31:1165-75
Korba, B E; Cote, P; Hornbuckle, W et al. (2000) Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks. Antiviral Res 45:19-32
Korba, B E; Cote, P; Hornbuckle, W et al. (2000) Enhanced antiviral benefit of combination therapy with lamivudine and alpha interferon against WHV replication in chronic carrier woodchucks. Antivir Ther 5:95-104
Chen, H S; Miller, R H; Hornbuckle, W E et al. (1998) Titration of recombinant woodchuck hepatitis virus DNA in adult woodchucks. J Med Virol 54:92-4
Hostetler, K Y; Beadle, J R; Kini, G D et al. (1997) Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro. Biochem Pharmacol 53:1815-22
Korba, B A; Xie, H; Wright, K N et al. (1996) Liver-targeted antiviral nucleosides: enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo. Hepatology 23:958-63
Korba, B E; Boyd, M R (1996) Penciclovir is a selective inhibitor of hepatitis B virus replication in cultured human hepatoblastoma cells. Antimicrob Agents Chemother 40:1282-4
Casey, J L; Gerin, J L (1995) Hepatitis D virus RNA editing: specific modification of adenosine in the antigenomic RNA. J Virol 69:7593-600
Korba, B E; Gerin, J L (1995) Antisense oligonucleotides are effective inhibitors of hepatitis B virus replication in vitro. Antiviral Res 28:225-42
Langley, R J; Hirsch, V M; O'Brien, S J et al. (1994) Nucleotide sequence analysis of puma lentivirus (PLV-14): genomic organization and relationship to other lentiviruses. Virology 202:853-64

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