Abstract

This contract will support investigation of the role of natural suppressor cells in engraftment of bone marrow. Initial studies will be done in a murine model, followed by preliminary studies in the human system. These studies are being undertaken to further elucidate the cellular mechanisms involved in engraftment and to develop a clinically applicable model to be used in human transplantation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research and Development Contracts (N01)
Project #
N01AI085001-006
Application #
2297307
Study Section
Project Start
1988-09-30
Project End
1993-09-29
Budget Start
1991-06-14
Budget End
1992-09-29
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Dejbakhsh-Jones, S; Jerabek, L; Weissman, I L et al. (1995) Extrathymic maturation of alpha beta T cells from hemopoietic stem cells. J Immunol 155:3338-44
Van Vlasselaer, P; Fischer, M; Strober, S et al. (1991) Regulation of thymocyte proliferation by alpha beta TcR+ CD3+ CD4- CD8- cloned natural suppressor (NS) cells. Cell Immunol 136:1-15
Van Vlasselaer, P; Strober, S (1991) Alpha beta TCR+ CD3+ CD4- CD8- cloned natural suppressor (NS) cells produce an immunosuppressive factor which is different from IFN-gamma and TGF-beta. Transplant Proc 23:200-2