This contract will support investigation of the role of natural suppressor cells in engraftment of bone marrow. Initial studies will be done in a murine model, followed by preliminary studies in the human system. These studies are being undertaken to further elucidate the cellular mechanisms involved in engraftment and to develop a clinically applicable model to be used in human transplantation.

Project Start
1988-09-30
Project End
1993-09-29
Budget Start
1992-04-10
Budget End
1993-03-29
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Stanford University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Dejbakhsh-Jones, S; Jerabek, L; Weissman, I L et al. (1995) Extrathymic maturation of alpha beta T cells from hemopoietic stem cells. J Immunol 155:3338-44
Van Vlasselaer, P; Fischer, M; Strober, S et al. (1991) Regulation of thymocyte proliferation by alpha beta TcR+ CD3+ CD4- CD8- cloned natural suppressor (NS) cells. Cell Immunol 136:1-15
Van Vlasselaer, P; Strober, S (1991) Alpha beta TCR+ CD3+ CD4- CD8- cloned natural suppressor (NS) cells produce an immunosuppressive factor which is different from IFN-gamma and TGF-beta. Transplant Proc 23:200-2